Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons

The equilibrium potential for GABA-A receptor mediated currents (EGABA) in neonatal central neurons is set at a relatively depolarized level, which is suggested to be caused by a low expression of K+/Cl- co-transporter (KCC2) but a relatively high expression of Na+-K+-Cl- cotransporter (NKCC1). Thet...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138215-e0138215
Hauptverfasser:	Yang, Bo, Rajput, Padmesh S, Kumar, Ujendra, Sastry, Bhagavatula R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Anesthesiology Animals Antisense RNA Brain research Brain slice preparation Chloride transport Depolarization Equilibrium GABA gamma-Aminobutyric Acid - metabolism Gene expression Genetic aspects Glutamic acid receptors (metabotropic) Hippocampus Hippocampus - cytology Hippocampus - physiology Juveniles Kinases Laboratories Male Medical research mRNA Neonates Neurons Neurosciences Newborn babies Patch-Clamp Techniques Pharmaceutical sciences Phosphorylation Physiological aspects Potassium-chloride cotransporter Pyramidal cells Pyramidal Cells - cytology Pyramidal Cells - metabolism Rats Rats, Wistar Receptor, Metabotropic Glutamate 5 - metabolism Receptors Receptors, GABA-A - metabolism Receptors, Metabotropic Glutamate - metabolism Rodents Stratum radiatum γ-Aminobutyric acid A receptors
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