Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells

Epidemiological studies have associated high levels of airborne particulate matter (PM) with increased respiratory diseases. In order to investigate the mechanisms of air pollution-induced lung toxicity in humans, human bronchial epithelial cells (16HBE) were exposed to various concentrations of par...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138267
Hauptverfasser:	Zhou, Zhixiang, Liu, Yanghua, Duan, Fengkui, Qin, Mengnan, Wu, Fengchang, Sheng, Wang, Yang, Lixin, Liu, Jianguo, He, Kebin
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - pharmacology Air pollution Airborne particulates Bioengineering Biological effects Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Cells, Cultured China Cytochrome P450 Cytokines Environmental science Enzyme-linked immunosorbent assay Epidemiology Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Exposure Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Genes Humans Immune response Immune system Inflammation Inhalation Exposure - analysis Interleukin 6 Interleukin 8 Laboratories Life sciences Lung diseases MAP kinase Metabolic response Outdoor air quality Oxidative stress Particulate emissions Particulate matter Particulate Matter - pharmacology Pollutants Reactive Oxygen Species - metabolism Respiratory diseases Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Ribonucleic acid RNA Toxicity Toxicology Transcriptome - drug effects
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