X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC

The N-isopropylammelide isopropylaminohydrolase from Pseudomonas sp. strain ADP, AtzC, provides the third hydrolytic step in the mineralization of s-triazine herbicides, such as atrazine. We obtained the X-ray crystal structure of AtzC at 1.84 Å with a weak inhibitor bound in the active site and the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137700
Hauptverfasser:	Balotra, Sahil, Warden, Andrew C, Newman, Janet, Briggs, Lyndall J, Scott, Colin, Peat, Thomas S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amidohydrolases - genetics Amidohydrolases - metabolism Amino acids Atrazine Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Carbonic anhydrase Carbonic anhydrases Catalysis Catalytic activity Chemistry Crystal structure Crystallography Crystallography, X-Ray Deoxyribonucleic acid DNA Docking Enzymes Evolution Genetic aspects Herbicides Histidine Hydrolases Manufacturers Mineralization Mutagenesis Mutagenesis, Site-Directed Physiological aspects Physiology Protein Conformation Protein expression Proteins Pseudomonas Site-directed mutagenesis Substrates Triazine Triazine pesticides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!