Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis

Routine use of antifibrinolytic agents in spine surgery is still an issue of debate. To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA, traditionally known as Amicar) in reducing periope...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137886-e0137886
Hauptverfasser:	Wang, Meng, Zheng, Xin-Feng, Jiang, Lei-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Antifibrinolytic agents Antifibrinolytic Agents - therapeutic use Blood Blood Loss, Surgical - prevention & control Blood Transfusion Bone surgery Care and treatment Clinical trials Confidence intervals Development and progression Effectiveness Evaluation Health aspects Humans Joint surgery Meta-analysis Mortality Orthopedic surgery Patient outcomes Patients Pharmacology Risk factors Safety Scoliosis Scoliosis - surgery Spinal Fusion - adverse effects Spine Studies Surgery Systematic review Thromboembolism Transfusion Treatment Outcome
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