Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315

An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M. tuberculosis population there is a proportion of bacteria that are drug-tolerant; this might be becaus...

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Veröffentlicht in:	PloS one 2015, Vol.10 (9), p.e0138253-e0138253
Hauptverfasser:	Jeeves, Rose E, Marriott, Alice A N, Pullan, Steven T, Hatch, Kim A, Allnutt, Jon C, Freire-Martin, Irene, Hendon-Dunn, Charlotte L, Watson, Robert, Witney, Adam A, Tyler, Richard H, Arnold, Catherine, Marsh, Philip D, McHugh, Timothy D, Bacon, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Antibiotics Antisense RNA Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bacilli Bacteria Bacterial Proteins - genetics Besra Catalase Catalase - genetics Chemostats Chemotherapy Clinical isolates Codon DNA Mutational Analysis Drug resistance Drug Resistance, Microbial - genetics Efflux Fitness Gene expression Gene Expression Profiling Gene Expression Regulation, Bacterial - drug effects Gene Expression Regulation, Enzymologic - drug effects Growth rate Humans Hypotheses Isoniazid Isoniazid - pharmacology Isoniazid - therapeutic use Metabolism Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Peroxide Phenotypes Point Mutation Polymorphism, Single Nucleotide Populations Public health Replication Reproductive fitness Ribonucleic acid RNA Serine - genetics Single-nucleotide polymorphism Tuberculosis Tuberculosis, Multidrug-Resistant - genetics Tuberculosis, Multidrug-Resistant - microbiology
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