Neutron Activated Samarium-153 Microparticles for Transarterial Radioembolization of Liver Tumour with Post-Procedure Imaging Capabilities
Samarium-153 (153Sm) styrene divinylbenzene microparticles were developed as a surrogate for Yttrium-90 (90Y) microspheres in liver radioembolization therapy. Unlike the pure beta emitter 90Y, 153Sm possess both therapeutic beta and diagnostic gamma radiations, making it possible for post-procedure...
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| Veröffentlicht in: | PloS one 2015-09, Vol.10 (9), p.e0138106-e0138106 |
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| creator | Hashikin, Nurul Ab Aziz Yeong, Chai-Hong Abdullah, Basri Johan Jeet Ng, Kwan-Hoong Chung, Lip-Yong Dahalan, Rehir Perkins, Alan Christopher |
| description | Samarium-153 (153Sm) styrene divinylbenzene microparticles were developed as a surrogate for Yttrium-90 (90Y) microspheres in liver radioembolization therapy. Unlike the pure beta emitter 90Y, 153Sm possess both therapeutic beta and diagnostic gamma radiations, making it possible for post-procedure imaging following therapy.
The microparticles were prepared using commercially available cation exchange resin, Amberlite IR-120 H+ (620-830 μm), which were reduced to 20-40 μm via ball mill grinding and sieve separation. The microparticles were labelled with 152Sm via ion exchange process with 152SmCl3, prior to neutron activation to produce radioactive 153Sm through 152Sm(n,γ)153Sm reaction. Therapeutic activity of 3 GBq was referred based on the recommended activity used in 90Y-microspheres therapy. The samples were irradiated in 1.494 x 10(12) n.cm(-2).s(-1) neutron flux for 6 h to achieve the nominal activity of 3.1 GBq.g(-1). Physicochemical characterisation of the microparticles, gamma spectrometry, and in vitro radiolabelling studies were carried out to study the performance and stability of the microparticles.
Fourier Transform Infrared (FTIR) spectroscopy of the Amberlite IR-120 resins showed unaffected functional groups, following size reduction of the beads. However, as shown by the electron microscope, the microparticles were irregular in shape. The radioactivity achieved after 6 h neutron activation was 3.104 ± 0.029 GBq. The specific activity per microparticle was 53.855 ± 0.503 Bq. Gamma spectrometry and elemental analysis showed no radioactive impurities in the samples. Radiolabelling efficiencies of 153Sm-Amberlite in distilled water and blood plasma over 48 h were excellent and higher than 95%.
The laboratory work revealed that the 153Sm-Amberlite microparticles demonstrated superior characteristics for potential use in hepatic radioembolization. |
| doi_str_mv | 10.1371/journal.pone.0138106 |
| format | Article |
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The microparticles were prepared using commercially available cation exchange resin, Amberlite IR-120 H+ (620-830 μm), which were reduced to 20-40 μm via ball mill grinding and sieve separation. The microparticles were labelled with 152Sm via ion exchange process with 152SmCl3, prior to neutron activation to produce radioactive 153Sm through 152Sm(n,γ)153Sm reaction. Therapeutic activity of 3 GBq was referred based on the recommended activity used in 90Y-microspheres therapy. The samples were irradiated in 1.494 x 10(12) n.cm(-2).s(-1) neutron flux for 6 h to achieve the nominal activity of 3.1 GBq.g(-1). Physicochemical characterisation of the microparticles, gamma spectrometry, and in vitro radiolabelling studies were carried out to study the performance and stability of the microparticles.
Fourier Transform Infrared (FTIR) spectroscopy of the Amberlite IR-120 resins showed unaffected functional groups, following size reduction of the beads. However, as shown by the electron microscope, the microparticles were irregular in shape. The radioactivity achieved after 6 h neutron activation was 3.104 ± 0.029 GBq. The specific activity per microparticle was 53.855 ± 0.503 Bq. Gamma spectrometry and elemental analysis showed no radioactive impurities in the samples. Radiolabelling efficiencies of 153Sm-Amberlite in distilled water and blood plasma over 48 h were excellent and higher than 95%.
The laboratory work revealed that the 153Sm-Amberlite microparticles demonstrated superior characteristics for potential use in hepatic radioembolization.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0138106</identifier><identifier>PMID: 26382059</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Amberlite (trademark) ; Ball milling ; Beads ; Beta radiation ; Beta rays ; Blood & organ donations ; Blood plasma ; Brachytherapy - methods ; Cancer therapies ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - therapy ; Care and treatment ; Cation exchange ; Cation exchanging ; Diagnosis ; Diagnostic imaging ; Diagnostic Imaging - methods ; Diagnostic systems ; Distilled water ; Divinylbenzene ; Embolization, Therapeutic - methods ; Emitters ; Emitters (electron) ; Energy ; Fourier transforms ; Functional groups ; Gamma rays ; Grinding mills ; Health aspects ; Humans ; Impurities ; Infrared spectroscopy ; Liver ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - therapy ; Lung cancer ; Lungs ; Materials Testing ; Medical ethics ; Medical technology ; Medicine ; Methods ; Microparticles ; Microspheres ; Neutron flux ; Neutrons ; Nuclear reactors ; Particle Size ; Postoperative Period ; Properties ; Radioactivity ; Radioisotopes - therapeutic use ; Radiolabelling ; Radionuclide Imaging ; Resins ; Resins, Synthetic - chemistry ; Resins, Synthetic - therapeutic use ; Samarium ; Samarium - therapeutic use ; Spectrometry ; Spectroscopy ; Styrene ; Therapy ; Transplants & implants ; Tumors ; Yttrium ; Yttrium Radioisotopes - therapeutic use</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0138106-e0138106</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hashikin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hashikin et al 2015 Hashikin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7014fa6c78fe5a72e9f9a8f9efa88772dba9ab675060828571e85d46e1e471e73</citedby><cites>FETCH-LOGICAL-c692t-7014fa6c78fe5a72e9f9a8f9efa88772dba9ab675060828571e85d46e1e471e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575131/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575131/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26382059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashikin, Nurul Ab Aziz</creatorcontrib><creatorcontrib>Yeong, Chai-Hong</creatorcontrib><creatorcontrib>Abdullah, Basri Johan Jeet</creatorcontrib><creatorcontrib>Ng, Kwan-Hoong</creatorcontrib><creatorcontrib>Chung, Lip-Yong</creatorcontrib><creatorcontrib>Dahalan, Rehir</creatorcontrib><creatorcontrib>Perkins, Alan Christopher</creatorcontrib><title>Neutron Activated Samarium-153 Microparticles for Transarterial Radioembolization of Liver Tumour with Post-Procedure Imaging Capabilities</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Samarium-153 (153Sm) styrene divinylbenzene microparticles were developed as a surrogate for Yttrium-90 (90Y) microspheres in liver radioembolization therapy. Unlike the pure beta emitter 90Y, 153Sm possess both therapeutic beta and diagnostic gamma radiations, making it possible for post-procedure imaging following therapy.
The microparticles were prepared using commercially available cation exchange resin, Amberlite IR-120 H+ (620-830 μm), which were reduced to 20-40 μm via ball mill grinding and sieve separation. The microparticles were labelled with 152Sm via ion exchange process with 152SmCl3, prior to neutron activation to produce radioactive 153Sm through 152Sm(n,γ)153Sm reaction. Therapeutic activity of 3 GBq was referred based on the recommended activity used in 90Y-microspheres therapy. The samples were irradiated in 1.494 x 10(12) n.cm(-2).s(-1) neutron flux for 6 h to achieve the nominal activity of 3.1 GBq.g(-1). Physicochemical characterisation of the microparticles, gamma spectrometry, and in vitro radiolabelling studies were carried out to study the performance and stability of the microparticles.
Fourier Transform Infrared (FTIR) spectroscopy of the Amberlite IR-120 resins showed unaffected functional groups, following size reduction of the beads. However, as shown by the electron microscope, the microparticles were irregular in shape. The radioactivity achieved after 6 h neutron activation was 3.104 ± 0.029 GBq. The specific activity per microparticle was 53.855 ± 0.503 Bq. Gamma spectrometry and elemental analysis showed no radioactive impurities in the samples. Radiolabelling efficiencies of 153Sm-Amberlite in distilled water and blood plasma over 48 h were excellent and higher than 95%.
The laboratory work revealed that the 153Sm-Amberlite microparticles demonstrated superior characteristics for potential use in hepatic radioembolization.</description><subject>Activation</subject><subject>Amberlite (trademark)</subject><subject>Ball milling</subject><subject>Beads</subject><subject>Beta radiation</subject><subject>Beta rays</subject><subject>Blood & organ donations</subject><subject>Blood plasma</subject><subject>Brachytherapy - methods</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Care and treatment</subject><subject>Cation exchange</subject><subject>Cation exchanging</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Diagnostic Imaging - methods</subject><subject>Diagnostic systems</subject><subject>Distilled water</subject><subject>Divinylbenzene</subject><subject>Embolization, Therapeutic - methods</subject><subject>Emitters</subject><subject>Emitters (electron)</subject><subject>Energy</subject><subject>Fourier transforms</subject><subject>Functional groups</subject><subject>Gamma rays</subject><subject>Grinding mills</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Impurities</subject><subject>Infrared spectroscopy</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - therapy</subject><subject>Lung cancer</subject><subject>Lungs</subject><subject>Materials Testing</subject><subject>Medical ethics</subject><subject>Medical technology</subject><subject>Medicine</subject><subject>Methods</subject><subject>Microparticles</subject><subject>Microspheres</subject><subject>Neutron flux</subject><subject>Neutrons</subject><subject>Nuclear reactors</subject><subject>Particle Size</subject><subject>Postoperative Period</subject><subject>Properties</subject><subject>Radioactivity</subject><subject>Radioisotopes - therapeutic use</subject><subject>Radiolabelling</subject><subject>Radionuclide Imaging</subject><subject>Resins</subject><subject>Resins, Synthetic - chemistry</subject><subject>Resins, Synthetic - therapeutic use</subject><subject>Samarium</subject><subject>Samarium - therapeutic use</subject><subject>Spectrometry</subject><subject>Spectroscopy</subject><subject>Styrene</subject><subject>Therapy</subject><subject>Transplants & implants</subject><subject>Tumors</subject><subject>Yttrium</subject><subject>Yttrium Radioisotopes - 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therapeutic use</topic><topic>Radiolabelling</topic><topic>Radionuclide Imaging</topic><topic>Resins</topic><topic>Resins, Synthetic - chemistry</topic><topic>Resins, Synthetic - therapeutic use</topic><topic>Samarium</topic><topic>Samarium - therapeutic use</topic><topic>Spectrometry</topic><topic>Spectroscopy</topic><topic>Styrene</topic><topic>Therapy</topic><topic>Transplants & implants</topic><topic>Tumors</topic><topic>Yttrium</topic><topic>Yttrium Radioisotopes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashikin, Nurul Ab Aziz</creatorcontrib><creatorcontrib>Yeong, Chai-Hong</creatorcontrib><creatorcontrib>Abdullah, Basri Johan Jeet</creatorcontrib><creatorcontrib>Ng, Kwan-Hoong</creatorcontrib><creatorcontrib>Chung, Lip-Yong</creatorcontrib><creatorcontrib>Dahalan, Rehir</creatorcontrib><creatorcontrib>Perkins, Alan Christopher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashikin, Nurul Ab Aziz</au><au>Yeong, Chai-Hong</au><au>Abdullah, Basri Johan Jeet</au><au>Ng, Kwan-Hoong</au><au>Chung, Lip-Yong</au><au>Dahalan, Rehir</au><au>Perkins, Alan Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutron Activated Samarium-153 Microparticles for Transarterial Radioembolization of Liver Tumour with Post-Procedure Imaging Capabilities</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-18</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0138106</spage><epage>e0138106</epage><pages>e0138106-e0138106</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Samarium-153 (153Sm) styrene divinylbenzene microparticles were developed as a surrogate for Yttrium-90 (90Y) microspheres in liver radioembolization therapy. Unlike the pure beta emitter 90Y, 153Sm possess both therapeutic beta and diagnostic gamma radiations, making it possible for post-procedure imaging following therapy.
The microparticles were prepared using commercially available cation exchange resin, Amberlite IR-120 H+ (620-830 μm), which were reduced to 20-40 μm via ball mill grinding and sieve separation. The microparticles were labelled with 152Sm via ion exchange process with 152SmCl3, prior to neutron activation to produce radioactive 153Sm through 152Sm(n,γ)153Sm reaction. Therapeutic activity of 3 GBq was referred based on the recommended activity used in 90Y-microspheres therapy. The samples were irradiated in 1.494 x 10(12) n.cm(-2).s(-1) neutron flux for 6 h to achieve the nominal activity of 3.1 GBq.g(-1). Physicochemical characterisation of the microparticles, gamma spectrometry, and in vitro radiolabelling studies were carried out to study the performance and stability of the microparticles.
Fourier Transform Infrared (FTIR) spectroscopy of the Amberlite IR-120 resins showed unaffected functional groups, following size reduction of the beads. However, as shown by the electron microscope, the microparticles were irregular in shape. The radioactivity achieved after 6 h neutron activation was 3.104 ± 0.029 GBq. The specific activity per microparticle was 53.855 ± 0.503 Bq. Gamma spectrometry and elemental analysis showed no radioactive impurities in the samples. Radiolabelling efficiencies of 153Sm-Amberlite in distilled water and blood plasma over 48 h were excellent and higher than 95%.
The laboratory work revealed that the 153Sm-Amberlite microparticles demonstrated superior characteristics for potential use in hepatic radioembolization.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26382059</pmid><doi>10.1371/journal.pone.0138106</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-09, Vol.10 (9), p.e0138106-e0138106 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1719288568 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Activation Amberlite (trademark) Ball milling Beads Beta radiation Beta rays Blood & organ donations Blood plasma Brachytherapy - methods Cancer therapies Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - therapy Care and treatment Cation exchange Cation exchanging Diagnosis Diagnostic imaging Diagnostic Imaging - methods Diagnostic systems Distilled water Divinylbenzene Embolization, Therapeutic - methods Emitters Emitters (electron) Energy Fourier transforms Functional groups Gamma rays Grinding mills Health aspects Humans Impurities Infrared spectroscopy Liver Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - therapy Lung cancer Lungs Materials Testing Medical ethics Medical technology Medicine Methods Microparticles Microspheres Neutron flux Neutrons Nuclear reactors Particle Size Postoperative Period Properties Radioactivity Radioisotopes - therapeutic use Radiolabelling Radionuclide Imaging Resins Resins, Synthetic - chemistry Resins, Synthetic - therapeutic use Samarium Samarium - therapeutic use Spectrometry Spectroscopy Styrene Therapy Transplants & implants Tumors Yttrium Yttrium Radioisotopes - therapeutic use |
| title | Neutron Activated Samarium-153 Microparticles for Transarterial Radioembolization of Liver Tumour with Post-Procedure Imaging Capabilities |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T14%3A03%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neutron%20Activated%20Samarium-153%20Microparticles%20for%20Transarterial%20Radioembolization%20of%20Liver%20Tumour%20with%20Post-Procedure%20Imaging%20Capabilities&rft.jtitle=PloS%20one&rft.au=Hashikin,%20Nurul%20Ab%20Aziz&rft.date=2015-09-18&rft.volume=10&rft.issue=9&rft.spage=e0138106&rft.epage=e0138106&rft.pages=e0138106-e0138106&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0138106&rft_dat=%3Cgale_plos_%3EA429059889%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1719288568&rft_id=info:pmid/26382059&rft_galeid=A429059889&rft_doaj_id=oai_doaj_org_article_dead7189ff174770bcca3605f75227f4&rfr_iscdi=true |