Tumor Necrosis Factor - Alpha Is Essential for Angiotensin II-Induced Ventricular Remodeling: Role for Oxidative Stress

The functional crosstalk between angiotensin II (Ang II) and tumor necrosis factor (TNF)-α has been shown to cause adverse left ventricular remodeling and hypertrophy in hypertension. Previous studies from our lab showed that mice lacking TNF-α (TNF-α-/-) have attenuated hypertensive response to Ang...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138372-e0138372
Hauptverfasser:	Sriramula, Srinivas, Francis, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - pharmacology Angiotensins Animals Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Body weight Bone morphogenetic proteins Cardiomegaly - metabolism Collagen Collagen (type I) Collagen (type III) Collagen Type I - metabolism Collagen Type III - metabolism Collagens Connective tissue growth factor Connective Tissue Growth Factor - metabolism Crosstalk Etanercept Fibrosis Fibrosis - metabolism Fibrosis - pathology Gene expression Heart Heart - drug effects Heart - physiopathology Heart diseases Heart hypertrophy Hypertension Hypertension - metabolism Hypertension - physiopathology Hypertrophy Infusion JNK protein Kinases Male MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice mRNA Myocardium - metabolism NAD(P)H oxidase NADPH Oxidases - metabolism Necrosis NF-kappa B - metabolism NF-κB protein Nitric oxide Oxidases Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxygen p38 Mitogen-Activated Protein Kinases - metabolism Reactive oxygen species Receptor, Angiotensin, Type 1 - metabolism RNA RNA, Messenger - metabolism Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signaling Transforming Growth Factor beta - metabolism Transforming growth factors Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Ventricle Ventricular Remodeling - drug effects Ventricular Remodeling - physiology Veterinary colleges
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