Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats

Exercise training is known to exert multiple beneficial effects including renal protection in type 2 diabetes mellitus and obesity. However, the mechanisms regulating these actions remain unclear. The present study evaluated the effects of chronic running exercise on the early stage of diabetic neph...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138037-e0138037
Hauptverfasser:	Ito, Daisuke, Cao, Pengyu, Kakihana, Takaaki, Sato, Emiko, Suda, Chihiro, Muroya, Yoshikazu, Ogawa, Yoshiko, Hu, Gaizun, Ishii, Tadashi, Ito, Osamu, Kohzuki, Masahiro, Kiyomoto, Hideyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Albumin Animals Blood Glucose - metabolism Blood Pressure Body weight Creatinine Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - enzymology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic nephropathy Disease Progression Excretion Exercise Experiments Glucose Glycosylation Health promotion Hyperglycemia Hypertension Insulin Insulin secretion Internal medicine Kidney diseases Kidneys Laboratories Male Medicine NAD(P)H oxidase Nephrology Nephropathy Neural stem cells Nitric oxide Nitric Oxide Synthase - metabolism Nitric-oxide synthase Obesity Oxidase Oxidases Oxidative stress Pharmacology Physical Conditioning, Animal Physical training Rats Rats, Zucker Rehabilitation Rodents Running Science Secretion Transplants & implants Type 2 diabetes University graduates Up-regulation Urine
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