Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB

High concentrations of arsenic, which can be occasionally found in drinking water, have been recognized as a global health problem. Exposure to arsenic can disrupt spatial memory; however, the underlying mechanism remains unclear. In the present study, we tested whether exercise could interfere with...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137810-e0137810
Hauptverfasser:	Sun, Bao-Fei, Wang, Qing-Qing, Yu, Zi-Jiang, Yu, Yan, Xiao, Chao-Lun, Kang, Chao-Sheng, Ge, Guo, Linghu, Yan, Zhu, Jun-De, Li, Yu-Mei, Li, Qiang-Ming, Luo, Shi-Peng, Yang, Dang, Li, Lin, Zhang, Wen-Yan, Tian, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic Arsenic - adverse effects Arsenic - pharmacology Arsenic content Behavior, Animal Body weight Brain Brain - drug effects Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism CREB-Binding Protein - metabolism Cyclic AMP response element-binding protein Dentate gyrus Disease Models, Animal Drinking water Exposure Gene Expression Regulation - drug effects Global health Hippocampus Impairment Kinases Long term memory Male Memory Memory Disorders - etiology Memory Disorders - physiopathology Memory Disorders - prevention & control Memory tasks Memory, Long-Term - drug effects Mice Neurosciences Object recognition Pattern recognition Physical Conditioning, Animal - methods Physical training Protein binding Rodents Spatial analysis Spatial memory Swimming Swimming - physiology
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