Evolution of the Antisense Overlap between Genes for Thyroid Hormone Receptor and Rev-erbα and Characterization of an Exonic G-Rich Element That Regulates Splicing of TRα2 mRNA

The α-thyroid hormone receptor gene (TRα) codes for two functionally distinct proteins: TRα1, the α-thyroid hormone receptor; and TRα2, a non-hormone-binding variant. The final exon of TRα2 mRNA overlaps the 3' end of Rev-erbα mRNA, which encodes another nuclear receptor on the opposite strand...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137893-e0137893
Hauptverfasser:	Munroe, Stephen H, Morales, Christopher H, Duyck, Tessa H, Waters, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Alternative Splicing Animals Antisense RNA Biological evolution Birds Comparative analysis Conformation Deoxyribonucleic acid Divergence DNA DNA, Antisense - genetics Enhancer Elements, Genetic Evolution Evolution, Molecular Evolutionary genetics Exons Gene expression Gene Expression Regulation Genes Genomes Guanine - metabolism Homology Humans Mammals Mammals - genetics Marsupials Molecular Sequence Data Mutation Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics Nucleotide sequence Physiology Platypus - genetics Proteins Reptiles & amphibians RNA, Messenger - metabolism Sequence Analysis, RNA Thyroid Thyroid gland Thyroid Hormone Receptors alpha - genetics Transcription Trends Vertebrates
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