Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease

The progressive neurodegenerative disorder Alzheimer's disease (AD) manifests as loss of cognitive functions, and finally leads to death of the affected individual. AD may result from accumulation of amyloid plaques. These amyloid plaques comprising of amyloid-beta 42 (Aβ42) polypeptides result...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137691
Hauptverfasser:	Cutler, Timothy, Sarkar, Ankita, Moran, Michael, Steffensmeier, Andrew, Puli, Oorvashi Roy, Mancini, Greg, Tare, Meghana, Gogia, Neha, Singh, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - genetics Amyloid precursor protein Animals Apoptosis Axon guidance Axons Biology Brain Brain - metabolism Brain - pathology Cancer Cell cycle Cell death Cognitive ability CREB-binding protein CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Cyclic AMP response element-binding protein Disease Models, Animal Drosophila Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Fruit flies Function analysis Genes Humans Insects Kinases Mice, Transgenic Mortality Neurodegeneration Neurodegenerative diseases Neurons Neuroprotection Peptide Fragments - biosynthesis Peptide Fragments - genetics Phenotypes Photoreceptors Polyglutamine Polypeptides Proteins Retina Retina - metabolism Retina - pathology Senile plaques Structure-function relationships Transgenic Trinucleotide repeat diseases
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