The abcEDCBA-Encoded ABC Transporter and the virB Operon-Encoded Type IV Secretion System of Brucella ovis Are Critical for Intracellular Trafficking and Survival in Ovine Monocyte-Derived Macrophages

Brucella ovis infection is associated with epididymitis, orchitis and infertility in rams. Most of the information available on B. ovis and host cell interaction has been generated using murine macrophages or epithelial cell lines, but the interaction between B. ovis and primary ovine macrophages ha...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0138131-e0138131
Hauptverfasser:	Macedo, Auricelio A, Silva, Ana P C, Mol, Juliana P S, Costa, Luciana F, Garcia, Luize N N, Araújo, Marcio S, Martins Filho, Olindo A, Paixão, Tatiane A, Santos, Renato L
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bacterial Secretion Systems - genetics Bacterial Secretion Systems - metabolism Biological Transport, Active Brucella ovis Brucella ovis - genetics Brucella ovis - metabolism Brucella ovis - pathogenicity Brucellosis Brucellosis - genetics Brucellosis - metabolism Calreticulin Cell lines Cell survival Chromosomes Coding Endoplasmic reticulum Epididymitis Epithelial cells Health aspects Infection Infections Infertility Intracellular Leprosy Life assessment Lymphocytes B Macrophages Macrophages - microbiology Macrophages - pathology Microbial Viability Monocytes Monocytes - microbiology Monocytes - pathology Mutants Mutation Nitric oxide Nitrogen Operon Orchitis Oxygen Pathogenesis Peripheral blood Reactive oxygen species Reliability analysis Secretion Sheep Survival
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