Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study

Diagnosing pediatric pneumonia is challenging in low-resource settings. The World Health Organization (WHO) has defined primary end-point radiological pneumonia for use in epidemiological and vaccine studies. However, radiography requires expertise and is often inaccessible. We hypothesized that pla...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137592-e0137592
Hauptverfasser:	Erdman, Laura K, D'Acremont, Valérie, Hayford, Kyla, Rajwans, Nimerta, Kilowoko, Mary, Kyungu, Esther, Hongoa, Philipina, Alamo, Leonor, Streiner, David L, Genton, Blaise, Kain, Kevin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - blood Ambulatory care Antibiotics Antigens, CD - blood Biomarkers Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Calcitonin - blood Calcitonin Gene-Related Peptide Chest Child, Preschool Children Chitinase Chitinase-3-Like Protein 1 Classification Clinical trials Cohort analysis Cohort Studies Confidence intervals Endoglin Enzyme-Linked Immunosorbent Assay Epidemiology Female Fever Health care networks Health psychology Hospitals Humans Immunization Infant Inflammation Lectins - blood Life assessment Likelihood Functions Likelihood ratio Logistic Models Low income groups Male Mathematical models Medicine Mortality Plasma levels Pneumonia Pneumonia - blood Pneumonia - diagnosis Pneumonia - diagnostic imaging Primary care Procalcitonin Protein Precursors - blood Proteins Proteomics Public health Radiography Receptor, TIE-2 - blood Receptors, Cell Surface - blood Regression Analysis Respiratory syncytial virus ROC Curve Sensitivity and Specificity Standard error Statistical analysis Streptococcus infections Streptococcus pneumoniae Studies Tanzania Vaccines Von Willebrand factor von Willebrand Factor - metabolism
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