Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231

Omega 3 (n3) and Omega 6 (n6) polyunsaturated fatty acids (PUFAs) have been reported to exhibit opposing roles in cancer progression. Our objective was to determine whether different ratios of n6/n3 (AA/EPA+DHA) FAs could modulate the cell viability, lipid peroxidation, total cellular fatty acid com...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0136542-e0136542
Hauptverfasser:	Mansara, Prakash P, Deshpande, Rashmi A, Vaidya, Milind M, Kaul-Ghanekar, Ruchika
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Linolenic Acid - pharmacology Binding proteins Biotechnology Blotting, Western Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - metabolism Cancer Care and treatment Cell Line, Tumor - chemistry Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Cell Proliferation - drug effects Cell survival Cell Survival - drug effects College campuses Cyclin-dependent kinase inhibitor p21 Development and progression Docosahexaenoic Acids - pharmacology Dose-Response Relationship, Drug Eicosapentaenoic Acid - pharmacology Fatty acid composition Fatty acids Fatty Acids, Omega-3 - analysis Fatty Acids, Omega-3 - pharmacology Fatty Acids, Omega-6 - analysis Fatty Acids, Omega-6 - pharmacology Female Fish oils Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Humans Kinases Lipid Peroxidation Lipids Matrix Attachment Region Binding Proteins - metabolism MCF-7 Cells - chemistry MCF-7 Cells - drug effects MCF-7 Cells - metabolism Patient outcomes Peroxidation Polyunsaturated fatty acids Proteins Rodents Tumor cell lines Tumor suppressor genes Tumors
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