Benzoic Acid-Inducible Gene Expression in Mycobacteria

Conditional expression is a powerful tool to investigate the role of bacterial genes. Here, we adapt the Pseudomonas putida-derived positively regulated XylS/Pm expression system to control inducible gene expression in Mycobacterium smegmatis and Mycobacterium tuberculosis, the causative agent of hu...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0134544-e0134544
Hauptverfasser:	Dragset, Marte S, Barczak, Amy K, Kannan, Nisha, Mærk, Mali, Flo, Trude H, Valla, Svein, Rubin, Eric J, Steigedal, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Benzoic acid Benzoic Acid - pharmacology Binding sites Cancer Drug dosages Drug resistance E coli Escherichia coli Gene expression Gene Expression Regulation, Bacterial Genetic aspects Genetic Vectors Gram-positive bacteria Humans Immunology Infectious diseases Inflammation Medical research Medicine Mycobacteria Mycobacterium smegmatis Mycobacterium smegmatis - genetics Mycobacterium smegmatis - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Physiological aspects Promoter Regions, Genetic Pseudomonas putida Pseudomonas putida - genetics Public health Science Trans-Activators - biosynthesis Trans-Activators - genetics Tuberculosis Tuberculosis - genetics Tuberculosis - microbiology
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