Ischemic Preconditioning Mediates Neuroprotection against Ischemia in Mouse Hippocampal CA1 Neurons by Inducing Autophagy

The hippocampal CA1 region is sensitive to hypoxic and ischemic injury but can be protected by ischemic preconditioning (IPC). However, the mechanism through which IPC protects hippocampal CA1 neurons is still under investigation. Additionally, the role of autophagy in determining the fate of hippoc...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137146-e0137146
Hauptverfasser:	Gao, Chunlin, Cai, Ying, Zhang, Xuebin, Huang, Huiling, Wang, Jin, Wang, Yajing, Tong, Xiaoguang, Wang, Jinhuan, Wu, Jialing
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Apoptosis Autophagy Autophagy (Cytology) Biodegradable materials CA1 Region, Hippocampal - cytology Care and treatment Carotid artery Cell death Cell Survival Cerebral blood flow Deprivation Female Gene expression Genetic aspects Hippocampus Hypoxia Ischemia Ischemic Preconditioning Laboratories Mice Mice, Inbred C57BL Neurology Neurons Neurons - cytology Neuroprotection Neurosciences Neurosurgery Occlusion Oxygen Phagocytosis Phosphorylation Physiological aspects Preconditioning Pregnancy Reperfusion Injury - prevention & control Rodents Studies Survival Veins & arteries
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