Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression

We have reported a high expression of IGF-I in pancreatic islet β-cells of transgenic mice under the metallothionein promoter. cDNA microarray analysis of the islets revealed that the expression of 82 genes was significantly altered compared to wild-type mice. Of these, 11β-hydroxysteroid dehydrogen...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0136656
Hauptverfasser:	Chowdhury, Subrata, Grimm, Larson, Gong, Ying Jia Kate, Wang, Beixi, Li, Bing, Srikant, Coimbatore B, Gao, Zu-hua, Liu, Jun-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - biosynthesis 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics 11β-Hydroxysteroid dehydrogenase Adipose tissue Animals Apoptosis Cell Proliferation Cell survival Corticosterone Corticosterone - analogs & derivatives Corticosterone - metabolism Cortisone Dehydrogenase Dehydrogenases Dexamethasone Dexamethasone - administration & dosage Diabetes DNA microarrays Endocrinology Enzymatic activity Enzyme activity Enzymes Gene expression Glucagon Glucagon - genetics Glucagon - metabolism Glucocorticoids Glucose Glucose - metabolism Humans Hydrocortisone Hydroxysteroids Immunofluorescence Insulin Insulin - genetics Insulin - metabolism Insulin Secretion Insulin-like growth factor I Insulin-Like Growth Factor I - biosynthesis Insulin-Like Growth Factor I - genetics Insulin-like growth factors Insulinoma Islets of Langerhans Islets of Langerhans - enzymology Islets of Langerhans - metabolism Kinases Laboratories Liver Liver - drug effects Liver - metabolism Localization Medicine Metabolism Metallothionein Mice Mice, Transgenic Obesity Oligonucleotide Array Sequence Analysis Pancreas Proteins Rodents Transgenic animals Transgenic mice
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