MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression

Myeloid-derived suppressor cells (MDSCs) constitute one of the major populations that potently suppress anti-tumor immune responses and favor tumor growth in tumor microenvironment. However, the mechanism(s) regulating the differentiation and suppressive function of tumor-associated MDSCs remain(s)...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0135867-e0135867
Hauptverfasser:	Mei, Shiyue, Xin, Jiaxuan, Liu, Yu, Zhang, Yuan, Liang, Xue, Su, Xiaomin, Yan, Hui, Huang, Yugang, Yang, Rongcun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Base Sequence Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - immunology Cell Line, Tumor DNA-Binding Proteins - genetics Enzyme Activation - drug effects Enzyme Activation - genetics Enzyme Activation - immunology Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genotype & phenotype Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocytes Homology Immune response Immune Tolerance - drug effects Immune Tolerance - genetics Immunology Immunotherapy Laboratories Male Medical research Medicine Melanoma Mice MicroRNA MicroRNAs MicroRNAs - genetics miRNA Myeloid Cells - cytology Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - metabolism Neutrophils Ovarian cancer Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN protein Ribonucleic acid RNA Stat3 protein STAT3 Transcription Factor - metabolism Suppressor cells T cell receptors Tensin Transcription Factors - genetics Tumors
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