Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes

Breast cancer patients who are resistant to neoadjuvant chemotherapy (NeoCT) have a poor prognosis. There is a pressing need to develop in vivo models of chemo resistant tumors to test novel therapeutics. We hypothesized that patient-derived breast cancer xenografts (BCXs) from chemo- naïve and chem...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0136851-e0136851
Hauptverfasser:	McAuliffe, Priscilla F, Evans, Kurt W, Akcakanat, Argun, Chen, Ken, Zheng, Xiaofeng, Zhao, Hao, Eterovic, Agda Karina, Sangai, Takafumi, Holder, Ashley M, Sharma, Chandeshwar, Chen, Huiqin, Do, Kim-Anh, Tarco, Emily, Gagea, Mihai, Naff, Katherine A, Sahin, Aysegul, Multani, Asha S, Black, Dalliah M, Mittendorf, Elizabeth A, Bedrosian, Isabelle, Mills, Gordon B, Gonzalez-Angulo, Ana Maria, Meric-Bernstam, Funda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animal models Animals Bioinformatics Biology Biopsy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Chemotherapy Chemotherapy, Adjuvant - methods Deoxyribonucleic acid Disease-Free Survival DNA DNA fingerprinting Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Female Genetic aspects Genetic fingerprinting Genetic transformation Genotypes Heterografts - pathology Humans Implantation In vivo methods and tests Lung cancer Mastectomy Metastases Metastasis Methods Mice Mice, Inbred BALB C Mice, Nude Middle Aged Mutation Neoadjuvant Therapy - methods Neoplasm Recurrence, Local - pathology Oncology Pathology Patients Prognosis Protein arrays Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Surgery Surgical implants Survival Transformation Tumors Veterinary medicine Xenografts Xenotransplantation
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