Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytok...
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| creator | Alvarado-Arnez, Lucia Elena Amaral, Evaldo P Sales-Marques, Carolinne Durães, Sandra M B Cardoso, Cynthia C Nunes Sarno, Euzenir Pacheco, Antonio G Lana, Francisco C F Moraes, Milton Ozório |
| description | Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine in mycobacterial pathogenesis and especially the -819C>T SNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is still missing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from meta-analysis supported a significant susceptibility association for the -819T allele, with pooled Odds Ratio of 1.22 (CI = 1.11-1.34) and P-value = 3x10(-5) confirming previous data. This result remained unaltered after inclusion of the Brazilian family-based groups (OR = 1.2, CI = 1.10-1.31, P-value = 2x10(-5)). Also, meta-analysis confirmed association of -592 A allele and leprosy outcome (OR = 1.24, CI = 1.03-1.50, P-value = 0.02). In support of this, linkage disequilibrium analysis in 1000 genomes AFR, EUR, ASN and AMR populations pointed to r(2) = 1.0 between the -592C>A and -819C>T SNPs. We found no evidence of association for the other IL10 polymorphisms analyzed for leprosy outcome. Our results reinforce the role of the -819C>T as a tag SNP (rs1800871) and its association with leprosy susceptibility. |
| doi_str_mv | 10.1371/journal.pone.0136282 |
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Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine in mycobacterial pathogenesis and especially the -819C>T SNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is still missing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from meta-analysis supported a significant susceptibility association for the -819T allele, with pooled Odds Ratio of 1.22 (CI = 1.11-1.34) and P-value = 3x10(-5) confirming previous data. This result remained unaltered after inclusion of the Brazilian family-based groups (OR = 1.2, CI = 1.10-1.31, P-value = 2x10(-5)). Also, meta-analysis confirmed association of -592 A allele and leprosy outcome (OR = 1.24, CI = 1.03-1.50, P-value = 0.02). In support of this, linkage disequilibrium analysis in 1000 genomes AFR, EUR, ASN and AMR populations pointed to r(2) = 1.0 between the -592C>A and -819C>T SNPs. We found no evidence of association for the other IL10 polymorphisms analyzed for leprosy outcome. Our results reinforce the role of the -819C>T as a tag SNP (rs1800871) and its association with leprosy susceptibility.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0136282</identifier><identifier>PMID: 26340474</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Alleles ; Analysis ; Brazil ; Cytokines ; Deoxyribonucleic acid ; Development and progression ; Disease ; DNA ; Female ; Gene Frequency ; Genes ; Genetic aspects ; Genetic Predisposition to Disease ; Genomes ; Haplotypes ; Humans ; Immunity, Innate - genetics ; Immunomodulation ; Infectious diseases ; Interleukin 1 ; Interleukin 10 ; Interleukin-10 - genetics ; Interleukin-10 - immunology ; Leprosy ; Leprosy - genetics ; Leprosy - immunology ; Leprosy - pathology ; Life assessment ; Linkage analysis ; Linkage Disequilibrium ; Male ; Medical ethics ; Meta-analysis ; Middle Aged ; Odds Ratio ; Pathogenesis ; Patients ; Physiological aspects ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Populations ; Promoter Regions, Genetic ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Studies ; Tuberculosis ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0136282-e0136282</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Alvarado-Arnez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Alvarado-Arnez et al 2015 Alvarado-Arnez et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9447b5f49037cd4d8b7823928d378aee6861885cf08eb274b040179f57e4875a3</citedby><cites>FETCH-LOGICAL-c692t-9447b5f49037cd4d8b7823928d378aee6861885cf08eb274b040179f57e4875a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26340474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvarado-Arnez, Lucia Elena</creatorcontrib><creatorcontrib>Amaral, Evaldo P</creatorcontrib><creatorcontrib>Sales-Marques, Carolinne</creatorcontrib><creatorcontrib>Durães, Sandra M B</creatorcontrib><creatorcontrib>Cardoso, Cynthia C</creatorcontrib><creatorcontrib>Nunes Sarno, Euzenir</creatorcontrib><creatorcontrib>Pacheco, Antonio G</creatorcontrib><creatorcontrib>Lana, Francisco C F</creatorcontrib><creatorcontrib>Moraes, Milton Ozório</creatorcontrib><title>Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine in mycobacterial pathogenesis and especially the -819C>T SNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is still missing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from meta-analysis supported a significant susceptibility association for the -819T allele, with pooled Odds Ratio of 1.22 (CI = 1.11-1.34) and P-value = 3x10(-5) confirming previous data. This result remained unaltered after inclusion of the Brazilian family-based groups (OR = 1.2, CI = 1.10-1.31, P-value = 2x10(-5)). Also, meta-analysis confirmed association of -592 A allele and leprosy outcome (OR = 1.24, CI = 1.03-1.50, P-value = 0.02). In support of this, linkage disequilibrium analysis in 1000 genomes AFR, EUR, ASN and AMR populations pointed to r(2) = 1.0 between the -592C>A and -819C>T SNPs. We found no evidence of association for the other IL10 polymorphisms analyzed for leprosy outcome. Our results reinforce the role of the -819C>T as a tag SNP (rs1800871) and its association with leprosy susceptibility.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Brazil</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>Disease</subject><subject>DNA</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Immunity, Innate - genetics</subject><subject>Immunomodulation</subject><subject>Infectious diseases</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - immunology</subject><subject>Leprosy</subject><subject>Leprosy - genetics</subject><subject>Leprosy - immunology</subject><subject>Leprosy - pathology</subject><subject>Life assessment</subject><subject>Linkage analysis</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical ethics</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Populations</subject><subject>Promoter Regions, Genetic</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Tuberculosis</subject><subject>Tumor necrosis factor-TNF</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7jr6D0QLguhFx3w1Sb1YKIsfAyMrft2GJE1mMrRNbVrZ-febcbrLVPZCcpFw8pz35Jy8SfIcgiXEDL7b-bFvZb3sfGuWAGKKOHqQnMMCo4wigB-enM-SJyHsAMgxp_RxcoYoJoAwcp5clCF47eTgfJt6m67WEKRffb1vfN9tXWhCKtsqXZuu92H_Pi3TL2aQWRkr74MLT5NHVtbBPJv2RfLz44cfl5-z9dWn1WW5zjQt0JAVhDCVW1IAzHRFKq4YR7hAvMKMS2Mop5DzXFvAjUKMKEAAZIXNmSGc5RIvkpdH3a72QUytBwEZBAVHOSCRWB2Jysud6HrXyH4vvHTib8D3GyH7wenaCIKKSuWIGIQ0sRIrQJHUMOdAWaa0iloXU7VRNabSph16Wc9E5zet24qN_yNITmOHNAq8mQR6_3s0YRCNC9rUtWyNH4_vppEFIKKv_kHv726iNjI24FrrY119EBUlQYwhxONAF8nyHiquyjROR59YF-OzhLezhMgM5nrYyDEEsfr-7f_Zq19z9vUJuzWyHrbB1-PBZWEOkiOoo71Cb-zdkCEQB5vfTkMcbC4mm8e0F6cfdJd062t8AxZg9GA</recordid><startdate>20150904</startdate><enddate>20150904</enddate><creator>Alvarado-Arnez, Lucia Elena</creator><creator>Amaral, Evaldo P</creator><creator>Sales-Marques, Carolinne</creator><creator>Durães, Sandra M B</creator><creator>Cardoso, Cynthia C</creator><creator>Nunes Sarno, Euzenir</creator><creator>Pacheco, Antonio G</creator><creator>Lana, Francisco C F</creator><creator>Moraes, Milton Ozório</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150904</creationdate><title>Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis</title><author>Alvarado-Arnez, Lucia Elena ; Amaral, Evaldo P ; Sales-Marques, Carolinne ; Durães, Sandra M B ; Cardoso, Cynthia C ; Nunes Sarno, Euzenir ; Pacheco, Antonio G ; Lana, Francisco C F ; Moraes, Milton Ozório</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9447b5f49037cd4d8b7823928d378aee6861885cf08eb274b040179f57e4875a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Brazil</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>Disease</topic><topic>DNA</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Immunity, Innate - genetics</topic><topic>Immunomodulation</topic><topic>Infectious diseases</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - immunology</topic><topic>Leprosy</topic><topic>Leprosy - genetics</topic><topic>Leprosy - immunology</topic><topic>Leprosy - pathology</topic><topic>Life assessment</topic><topic>Linkage analysis</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical ethics</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Populations</topic><topic>Promoter Regions, Genetic</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Tuberculosis</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alvarado-Arnez, Lucia Elena</creatorcontrib><creatorcontrib>Amaral, Evaldo P</creatorcontrib><creatorcontrib>Sales-Marques, Carolinne</creatorcontrib><creatorcontrib>Durães, Sandra M B</creatorcontrib><creatorcontrib>Cardoso, Cynthia C</creatorcontrib><creatorcontrib>Nunes Sarno, Euzenir</creatorcontrib><creatorcontrib>Pacheco, Antonio G</creatorcontrib><creatorcontrib>Lana, Francisco C F</creatorcontrib><creatorcontrib>Moraes, Milton Ozório</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alvarado-Arnez, Lucia Elena</au><au>Amaral, Evaldo P</au><au>Sales-Marques, Carolinne</au><au>Durães, Sandra M B</au><au>Cardoso, Cynthia C</au><au>Nunes Sarno, Euzenir</au><au>Pacheco, Antonio G</au><au>Lana, Francisco C F</au><au>Moraes, Milton Ozório</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-04</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0136282</spage><epage>e0136282</epage><pages>e0136282-e0136282</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine in mycobacterial pathogenesis and especially the -819C>T SNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is still missing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from meta-analysis supported a significant susceptibility association for the -819T allele, with pooled Odds Ratio of 1.22 (CI = 1.11-1.34) and P-value = 3x10(-5) confirming previous data. This result remained unaltered after inclusion of the Brazilian family-based groups (OR = 1.2, CI = 1.10-1.31, P-value = 2x10(-5)). Also, meta-analysis confirmed association of -592 A allele and leprosy outcome (OR = 1.24, CI = 1.03-1.50, P-value = 0.02). In support of this, linkage disequilibrium analysis in 1000 genomes AFR, EUR, ASN and AMR populations pointed to r(2) = 1.0 between the -592C>A and -819C>T SNPs. We found no evidence of association for the other IL10 polymorphisms analyzed for leprosy outcome. Our results reinforce the role of the -819C>T as a tag SNP (rs1800871) and its association with leprosy susceptibility.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26340474</pmid><doi>10.1371/journal.pone.0136282</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-09, Vol.10 (9), p.e0136282-e0136282 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1710982504 |
| source | PLoS (Open access); MEDLINE; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Adolescent Adult Alleles Analysis Brazil Cytokines Deoxyribonucleic acid Development and progression Disease DNA Female Gene Frequency Genes Genetic aspects Genetic Predisposition to Disease Genomes Haplotypes Humans Immunity, Innate - genetics Immunomodulation Infectious diseases Interleukin 1 Interleukin 10 Interleukin-10 - genetics Interleukin-10 - immunology Leprosy Leprosy - genetics Leprosy - immunology Leprosy - pathology Life assessment Linkage analysis Linkage Disequilibrium Male Medical ethics Meta-analysis Middle Aged Odds Ratio Pathogenesis Patients Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population Populations Promoter Regions, Genetic Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Tuberculosis Tumor necrosis factor-TNF |
| title | Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A23%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20IL10%20Polymorphisms%20and%20Leprosy:%20A%20Meta-Analysis&rft.jtitle=PloS%20one&rft.au=Alvarado-Arnez,%20Lucia%20Elena&rft.date=2015-09-04&rft.volume=10&rft.issue=9&rft.spage=e0136282&rft.epage=e0136282&rft.pages=e0136282-e0136282&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0136282&rft_dat=%3Cgale_plos_%3EA427722882%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1710982504&rft_id=info:pmid/26340474&rft_galeid=A427722882&rft_doaj_id=oai_doaj_org_article_429db524e22c4fa3b062ac1580bf7bcb&rfr_iscdi=true |