Low Expression of Mfn2 Is Associated with Mitochondrial Damage and Apoptosis of Ovarian Tissues in the Premature Ovarian Failure Model

This study aimed to construct a working model for detecting the mitochondrial damage and expression of Mfn2. It furthermore explored the pathogenesis of premature ovarian failure (POF) induced by cisplatin. Forty young female mice were divided randomly into two groups. The first was the treatment gr...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0136421-e0136421
Hauptverfasser:	Chen, Wenqi, Xu, Xiaoyan, Wang, Lingjuan, Bai, Ge, Xiang, Wenpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Apoptosis Apoptosis - physiology ATP Bax protein Bcl-2 protein Body weight Cell cycle Cisplatin Cisplatin - pharmacology Colorimetry Cytoplasm Damage detection Disease Models, Animal Electron microscopy Embryos Endoplasmic reticulum Energy metabolism Failure Family planning Female Follicles Gene expression Genetic aspects Gonadotropins GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - physiology Health aspects Hormones Hyperplasia Immunohistochemistry In Situ Nick-End Labeling Membrane potential Membrane Potential, Mitochondrial - physiology Metabolism Mice Microscopy, Electron, Transmission Mitochondria Mitochondria - physiology Mitochondrial DNA Ovarian diseases Ovary - metabolism Ovary - physiopathology Ovary - ultrastructure Pathogenesis Phosphomolybdic acid Pituitary (anterior) Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - physiopathology Properties Real-Time Polymerase Chain Reaction Reproductive status Risk factors Science Sex hormones Signal transduction Structure-function relationships Studies Transmission electron microscopy Ultrastructure Weight reduction Western blotting
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