Folliculogenesis Is Not Fully Inhibited during GnRH Analogues Treatment in Mice Challenging Their Efficiency to Preserve the Ovarian Reserve during Chemotherapy in This Model

As many chemotherapy regimens induce follicular depletion, fertility preservation became a major concern in young cancer patients. By maintaining follicles at the resting stage, gonadotropin-releasing hormone analogues (GnRHa) were proposed as an ovarian-protective option during chemotherapy. Howeve...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137164-e0137164
Hauptverfasser:	Horicks, Florence, Van Den Steen, Géraldine, Houben, Sarah, Englert, Yvon, Demeestere, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects Apoptosis Cancer Cancer therapies Cell division Chemotherapy Complications and side effects Cyclophosphamide Cyclophosphamide - adverse effects Depletion Dose-Response Relationship, Drug Drug therapy Endocrinology Female Fertility Follicle-stimulating hormone Follicles Folliculogenesis Gonadorelin Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Gonadotropins Granulosa cells Gynecology Infertility Injection Laboratories Mice Mice, Inbred C57BL Mice, Inbred CBA Models, Animal Obstetrics Ovarian cancer Ovarian Follicle - cytology Ovarian Follicle - drug effects Ovarian Reserve - drug effects Patient outcomes Physiological aspects Pituitary Pituitary (anterior) Pituitary-gonadal axis Preservation Quality of life Rodents Secretion Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!