Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study
Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of car...
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| creator | Fernández-Palomeque, Carlos Grau, Andres Perelló, Joan Sanchis, Pilar Isern, Bernat Prieto, Rafel M Costa-Bauzá, Antonia Caldés, Onofre J Bonnin, Oriol Garcia-Raja, Ana Bethencourt, Armando Grases, Felix |
| description | Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution. |
| doi_str_mv | 10.1371/journal.pone.0136560 |
| format | Article |
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Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0136560</identifier><identifier>PMID: 26322979</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aging ; Annuli ; Atherosclerosis ; Blood ; Blood levels ; Calcification ; Calcification (ectopic) ; Calcification (Physiology) ; Calcification, Physiologic ; Calcinosis - blood ; Calcinosis - urine ; Calcium ; Calcium (blood) ; Calcium phosphates ; Cardiomyopathies - blood ; Cardiomyopathies - epidemiology ; Cardiomyopathies - urine ; Cardiovascular disease ; Cardiovascular diseases ; Coronary vessels ; Cross-Sectional Studies ; Crystallization ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Durapatite - metabolism ; Echocardiography ; Excretion ; Female ; Food consumption ; Geriatrics ; Health risks ; Health sciences ; Heart ; Heart Valve Diseases - blood ; Heart Valve Diseases - epidemiology ; Heart Valve Diseases - urine ; Heart Valves - pathology ; Humans ; Hydroxyapatite ; Hydroxyapatites ; Hypercholesterolemia ; Hypercholesterolemia - epidemiology ; Hypertension ; Kidney diseases ; Laboratories ; Leukocyte Count ; Leukocytes ; Male ; Mitral Valve - pathology ; Multivariate analysis ; Older people ; Phosphates - blood ; Physiological aspects ; Phytic Acid - urine ; Population ; Population studies ; R&D ; Research & development ; Risk analysis ; Risk Factors ; Soft tissues ; Supersaturation ; Urine ; White blood cells</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0136560-e0136560</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Fernández-Palomeque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Fernández-Palomeque et al 2015 Fernández-Palomeque et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-57cccbf1eda8c440edde3fcb031abd6f41dd667cf2aa7182869f1d7fb380a8db3</citedby><cites>FETCH-LOGICAL-c743t-57cccbf1eda8c440edde3fcb031abd6f41dd667cf2aa7182869f1d7fb380a8db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554994/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554994/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26322979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lionetti, Vincenzo</contributor><creatorcontrib>Fernández-Palomeque, Carlos</creatorcontrib><creatorcontrib>Grau, Andres</creatorcontrib><creatorcontrib>Perelló, Joan</creatorcontrib><creatorcontrib>Sanchis, Pilar</creatorcontrib><creatorcontrib>Isern, Bernat</creatorcontrib><creatorcontrib>Prieto, Rafel M</creatorcontrib><creatorcontrib>Costa-Bauzá, Antonia</creatorcontrib><creatorcontrib>Caldés, Onofre J</creatorcontrib><creatorcontrib>Bonnin, Oriol</creatorcontrib><creatorcontrib>Garcia-Raja, Ana</creatorcontrib><creatorcontrib>Bethencourt, Armando</creatorcontrib><creatorcontrib>Grases, Felix</creatorcontrib><title>Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.</description><subject>Aged</subject><subject>Aging</subject><subject>Annuli</subject><subject>Atherosclerosis</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcification (Physiology)</subject><subject>Calcification, Physiologic</subject><subject>Calcinosis - blood</subject><subject>Calcinosis - urine</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Calcium phosphates</subject><subject>Cardiomyopathies - blood</subject><subject>Cardiomyopathies - epidemiology</subject><subject>Cardiomyopathies - urine</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Crystallization</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Durapatite - metabolism</subject><subject>Echocardiography</subject><subject>Excretion</subject><subject>Female</subject><subject>Food consumption</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>Health sciences</subject><subject>Heart</subject><subject>Heart Valve Diseases - blood</subject><subject>Heart Valve Diseases - epidemiology</subject><subject>Heart Valve Diseases - urine</subject><subject>Heart Valves - pathology</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Hydroxyapatites</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - epidemiology</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Mitral Valve - pathology</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Phosphates - blood</subject><subject>Physiological aspects</subject><subject>Phytic Acid - urine</subject><subject>Population</subject><subject>Population studies</subject><subject>R&D</subject><subject>Research & development</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Soft tissues</subject><subject>Supersaturation</subject><subject>Urine</subject><subject>White blood cells</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fv0zAQxyMEYmPwDRBYQkLw0GLHjp3wgDRVAyZV2rSxvVoX-9J6cuMSJ4Xy6XHXblrRHlAeEp1____lzndZ9prRMeOKfboJQ9eCHy9Di2PKuCwkfZIdsornI5lT_vTB90H2IsYbSgteSvk8O8glz_NKVYfZnwv00LvQxrlbkhr7X4gtuepcC92aTHGFnoSGnM_XPfRIoLXkGvxq8NCRCXjjGmdu9cS16ZSceIudX5PzsBy2xp_JMZl0IcbRJZpNADy57Ae7fpk9a8BHfLV7H2VXX09-TL6PpmffTifH05FRgvejQhlj6oahhdIIQdFa5I2pKWdQW9kIZq2UyjQ5gGJlXsqqYVY1NS8plLbmR9nbre_Sh6h3bYuaKVoWUikpE3G6JWyAG73s3CIVrwM4fRsI3UxD1zvjURtalyAKKiRYgQyhqqRJaYoiVzVTJnl92WUb6gVag23fgd8z3T9p3VzPwkqLohBVJZLBh51BF34OGHu9cNGg99BiGLb_XVEu0uUeZe_-QR-vbkfNIBXg2iakvGZjqo9FrgqmhNhQ40eo9FhcOJNmrHEpvif4uCdITI-_-xkMMerTy4v_Z8-u99n3D9g5gu_nMfjhdkj3QbEFzWa6Omzum8yo3qzIXTf0ZkX0bkWS7M3DC7oX3e0E_ws-Ng4s</recordid><startdate>20150831</startdate><enddate>20150831</enddate><creator>Fernández-Palomeque, Carlos</creator><creator>Grau, Andres</creator><creator>Perelló, Joan</creator><creator>Sanchis, Pilar</creator><creator>Isern, Bernat</creator><creator>Prieto, Rafel M</creator><creator>Costa-Bauzá, Antonia</creator><creator>Caldés, Onofre J</creator><creator>Bonnin, Oriol</creator><creator>Garcia-Raja, Ana</creator><creator>Bethencourt, Armando</creator><creator>Grases, Felix</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150831</creationdate><title>Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study</title><author>Fernández-Palomeque, Carlos ; Grau, Andres ; Perelló, Joan ; Sanchis, Pilar ; Isern, Bernat ; Prieto, Rafel M ; Costa-Bauzá, Antonia ; Caldés, Onofre J ; Bonnin, Oriol ; Garcia-Raja, Ana ; Bethencourt, Armando ; Grases, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-57cccbf1eda8c440edde3fcb031abd6f41dd667cf2aa7182869f1d7fb380a8db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Annuli</topic><topic>Atherosclerosis</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcification (Physiology)</topic><topic>Calcification, Physiologic</topic><topic>Calcinosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Palomeque, Carlos</au><au>Grau, Andres</au><au>Perelló, Joan</au><au>Sanchis, Pilar</au><au>Isern, Bernat</au><au>Prieto, Rafel M</au><au>Costa-Bauzá, Antonia</au><au>Caldés, Onofre J</au><au>Bonnin, Oriol</au><au>Garcia-Raja, Ana</au><au>Bethencourt, Armando</au><au>Grases, Felix</au><au>Lionetti, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-31</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0136560</spage><epage>e0136560</epage><pages>e0136560-e0136560</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26322979</pmid><doi>10.1371/journal.pone.0136560</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-08, Vol.10 (8), p.e0136560-e0136560 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1708567766 |
| source | PubMed (Medline); MEDLINE; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; Public Library of Science (PLoS) |
| subjects | Aged Aging Annuli Atherosclerosis Blood Blood levels Calcification Calcification (ectopic) Calcification (Physiology) Calcification, Physiologic Calcinosis - blood Calcinosis - urine Calcium Calcium (blood) Calcium phosphates Cardiomyopathies - blood Cardiomyopathies - epidemiology Cardiomyopathies - urine Cardiovascular disease Cardiovascular diseases Coronary vessels Cross-Sectional Studies Crystallization Development and progression Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Durapatite - metabolism Echocardiography Excretion Female Food consumption Geriatrics Health risks Health sciences Heart Heart Valve Diseases - blood Heart Valve Diseases - epidemiology Heart Valve Diseases - urine Heart Valves - pathology Humans Hydroxyapatite Hydroxyapatites Hypercholesterolemia Hypercholesterolemia - epidemiology Hypertension Kidney diseases Laboratories Leukocyte Count Leukocytes Male Mitral Valve - pathology Multivariate analysis Older people Phosphates - blood Physiological aspects Phytic Acid - urine Population Population studies R&D Research & development Risk analysis Risk Factors Soft tissues Supersaturation Urine White blood cells |
| title | Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study |
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