Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC)

Diarrheal illness contributes to malnutrition, stunted growth, impaired cognitive development, and high morbidity rates in children worldwide. Enterotoxigenic Escherichia coli (ETEC) is a major contributor to this diarrheal disease burden. ETEC cause disease in the small intestine by means of coloni...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0136302-e0136302
Hauptverfasser:	Norton, Elizabeth B, Branco, Luis M, Clements, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacteria Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - immunology Binding Cell Line Children Cholera Cognitive ability Colonization Cytotoxicity Diarrhea Disease Models, Animal E coli Enterotoxigenic Escherichia coli - genetics Enterotoxigenic Escherichia coli - immunology Enterotoxins - chemistry Enterotoxins - genetics Enterotoxins - immunology Enzymatic activity Epidemiology Escherichia coli Escherichia coli Infections - epidemiology Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - immunology Heat Heat-labile enterotoxin Humans Immune response Immune system Immunity Immunity, Mucosal Immunization Immunogenicity Immunoglobulins Immunology Infections Lymphocytes B Malnutrition Mice Morbidity Mucous Membrane - immunology Mucous Membrane - microbiology Neutralization Tests Patients Protective antigen Protein Subunits - genetics Protein Subunits - immunology Proteins Small intestine Studies Thermal stability Tropical diseases Vaccines Vibrio cholerae
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