Probucol-Induced α-Tocopherol Deficiency Protects Mice against Malaria Infection

The emergence of malaria pathogens having resistance against antimalarials implies the necessity for the development of new drugs. Recently, we have demonstrated a resistance against malaria infection of α-tocopherol transfer protein knockout mice showing undetectable plasma levels of α-tocopherol,...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0136014
Hauptverfasser:	Herbas, Maria Shirely, Shichiri, Mototada, Ishida, Noriko, Kume, Aiko, Hagihara, Yoshihisa, Yoshida, Yasukazu, Suzuki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - antagonists & inhibitors alpha-Tocopherol - blood alpha-Tocopherol - pharmacology Animals Antimalarials - pharmacology Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Artemisinins - pharmacology Diet Dietary restrictions Dihydroartemisin Drug Administration Schedule Drug development Drug Synergism Drug Therapy, Combination Erythrocytes Female Infections Inoculation Lipid peroxidation Lipid Peroxidation - drug effects Lipids Malaria Malaria - blood Malaria - drug therapy Malaria - parasitology Malaria - pathology Male Mice Mice, Inbred C57BL Oxidative Stress Parasitemia - blood Parasitemia - drug therapy Parasitemia - pathology Parasites Peroxidation Plasma levels Plasmodium Plasmodium berghei - drug effects Plasmodium berghei - physiology Plasmodium falciparum Plasmodium yoelii - drug effects Plasmodium yoelii - physiology Probucol - pharmacology Proteins Science Survival Analysis Tocopherol Vector-borne diseases Vitamin E
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