Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive phosphorylation of splicing factors from the family...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134882-e0134882
Hauptverfasser:	Siqueira, Raoni Pais, Barbosa, Éverton de Almeida Alves, Polêto, Marcelo Depólo, Righetto, Germanna Lima, Seraphim, Thiago Vargas, Salgado, Rafael Locatelli, Ferreira, Joana Gasperazzo, Barros, Marcus Vinícius de Andrade, de Oliveira, Leandro Licursi, Laranjeira, Angelo Brunelli Albertoni, Almeida, Márcia Rogéria, Júnior, Abelardo Silva, Fietto, Juliana Lopes Rangel, Kobarg, Jörg, de Oliveira, Eduardo Basílio, Teixeira, Robson Ricardo, Borges, Júlio César, Yunes, Jose Andrés, Bressan, Gustavo Costa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Arginine Binding Sites Biosynthesis Blotting, Western Cancer Cell growth Cell Survival - drug effects Cells, Cultured Cytotoxicity Drug development Dynamic structural analysis Emission analysis Fluorescence Gene expression Gene Expression Regulation, Leukemic HeLa Cells HL-60 Cells Humans Inhibition Jurkat Cells K562 Cells Kinases Leukemia Leukemia - genetics Leukemia - metabolism Leukemia - pathology Melanoma Molecular chains Molecular docking Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Molecular Structure mRNA Myeloid leukemia Niacinamide - analogs & derivatives Niacinamide - chemistry Niacinamide - metabolism Niacinamide - pharmacology Ovarian cancer Pharmacology Phosphatase Phosphorylation Piperidines - chemistry Piperidines - metabolism Piperidines - pharmacology Protein Binding Protein kinase Protein Structure, Tertiary Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Proteins Reverse Transcriptase Polymerase Chain Reaction Site selection Spectrometry, Fluorescence Splicing factors Tryptophan Tumor cell lines Vascular endothelial growth factor Viability
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