The Impact of Accelerated Right Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Cue-Reactivity: An fMRI Study on Craving in Recently Detoxified Alcohol-Dependent Patients
In alcohol-dependent patients craving is a difficult-to-treat phenomenon. It has been suggested that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may have beneficial effects. However, exactly how this application exerts its effect on the underlying craving neurocircuit is...
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| description | In alcohol-dependent patients craving is a difficult-to-treat phenomenon. It has been suggested that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may have beneficial effects. However, exactly how this application exerts its effect on the underlying craving neurocircuit is currently unclear. In an effort to induce alcohol craving and to maximize detection of HF-rTMS effects to cue-induced alcohol craving, patients were exposed to a block and event-related alcohol cue-reactivity paradigm while being scanned with fMRI. Hence, we assessed the effect of right dorsolateral prefrontal cortex (DLPFC) stimulation on cue-induced and general alcohol craving, and the related craving neurocircuit. Twenty-six recently detoxified alcohol-dependent patients were included. First, we evaluated the impact of one sham-controlled stimulation session. Second, we examined the effect of accelerated right DLPFC HF-rTMS treatment: here patients received 15 sessions in an open label accelerated design, spread over 4 consecutive days. General craving significantly decreased after 15 active HF-rTMS sessions. However, cue-induced alcohol craving was not altered. Our brain imaging results did not show that the cue-exposure affected the underlying craving neurocircuit after both one and fifteen active HF-rTMS sessions. Yet, brain activation changes after one and 15 HF-rTMS sessions, respectively, were observed in regions associated with the extended reward system and the default mode network, but only during the presentation of the event-related paradigm. Our findings indicate that accelerated HF-rTMS applied to the right DLPFC does not manifestly affect the craving neurocircuit during an alcohol-related cue-exposure, but instead it may influence the attentional network. |
| doi_str_mv | 10.1371/journal.pone.0136182 |
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It has been suggested that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may have beneficial effects. However, exactly how this application exerts its effect on the underlying craving neurocircuit is currently unclear. In an effort to induce alcohol craving and to maximize detection of HF-rTMS effects to cue-induced alcohol craving, patients were exposed to a block and event-related alcohol cue-reactivity paradigm while being scanned with fMRI. Hence, we assessed the effect of right dorsolateral prefrontal cortex (DLPFC) stimulation on cue-induced and general alcohol craving, and the related craving neurocircuit. Twenty-six recently detoxified alcohol-dependent patients were included. First, we evaluated the impact of one sham-controlled stimulation session. Second, we examined the effect of accelerated right DLPFC HF-rTMS treatment: here patients received 15 sessions in an open label accelerated design, spread over 4 consecutive days. General craving significantly decreased after 15 active HF-rTMS sessions. However, cue-induced alcohol craving was not altered. Our brain imaging results did not show that the cue-exposure affected the underlying craving neurocircuit after both one and fifteen active HF-rTMS sessions. Yet, brain activation changes after one and 15 HF-rTMS sessions, respectively, were observed in regions associated with the extended reward system and the default mode network, but only during the presentation of the event-related paradigm. Our findings indicate that accelerated HF-rTMS applied to the right DLPFC does not manifestly affect the craving neurocircuit during an alcohol-related cue-exposure, but instead it may influence the attentional network.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0136182</identifier><identifier>PMID: 26295336</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Addictions ; Adult ; Alcohol ; Alcohol use ; Alcoholism ; Alcoholism - physiopathology ; Alcoholism - therapy ; Alcohols ; Attention ; Automation ; Brain ; Brain mapping ; Brain research ; Care and treatment ; Circuits ; Complications and side effects ; Cues ; Diagnosis ; Exposure ; Female ; Functional Laterality ; Functional magnetic resonance imaging ; Humans ; Magnetic brain stimulation ; Magnetic fields ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Middle Aged ; Nerve Net - physiopathology ; Neuroimaging ; Neurosciences ; Paradigms ; Patients ; Prefrontal cortex ; Prefrontal Cortex - physiopathology ; Psychiatry ; Reinforcement ; Reward ; Systematic review ; Transcranial Magnetic Stimulation</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0136182</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Herremans et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Herremans et al 2015 Herremans et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-a6613cb58e914bd18cecf611fe8342103e17f13220bbf099e322bc7ea9693413</citedby><cites>FETCH-LOGICAL-c593t-a6613cb58e914bd18cecf611fe8342103e17f13220bbf099e322bc7ea9693413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546410/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546410/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26295336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Langguth, Berthold</contributor><creatorcontrib>Herremans, Sarah C</creatorcontrib><creatorcontrib>Van Schuerbeek, Peter</creatorcontrib><creatorcontrib>De Raedt, Rudi</creatorcontrib><creatorcontrib>Matthys, Frieda</creatorcontrib><creatorcontrib>Buyl, Ronald</creatorcontrib><creatorcontrib>De Mey, Johan</creatorcontrib><creatorcontrib>Baeken, Chris</creatorcontrib><title>The Impact of Accelerated Right Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Cue-Reactivity: An fMRI Study on Craving in Recently Detoxified Alcohol-Dependent Patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In alcohol-dependent patients craving is a difficult-to-treat phenomenon. 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It has been suggested that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may have beneficial effects. However, exactly how this application exerts its effect on the underlying craving neurocircuit is currently unclear. In an effort to induce alcohol craving and to maximize detection of HF-rTMS effects to cue-induced alcohol craving, patients were exposed to a block and event-related alcohol cue-reactivity paradigm while being scanned with fMRI. Hence, we assessed the effect of right dorsolateral prefrontal cortex (DLPFC) stimulation on cue-induced and general alcohol craving, and the related craving neurocircuit. Twenty-six recently detoxified alcohol-dependent patients were included. First, we evaluated the impact of one sham-controlled stimulation session. Second, we examined the effect of accelerated right DLPFC HF-rTMS treatment: here patients received 15 sessions in an open label accelerated design, spread over 4 consecutive days. General craving significantly decreased after 15 active HF-rTMS sessions. However, cue-induced alcohol craving was not altered. Our brain imaging results did not show that the cue-exposure affected the underlying craving neurocircuit after both one and fifteen active HF-rTMS sessions. Yet, brain activation changes after one and 15 HF-rTMS sessions, respectively, were observed in regions associated with the extended reward system and the default mode network, but only during the presentation of the event-related paradigm. Our findings indicate that accelerated HF-rTMS applied to the right DLPFC does not manifestly affect the craving neurocircuit during an alcohol-related cue-exposure, but instead it may influence the attentional network.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26295336</pmid><doi>10.1371/journal.pone.0136182</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Addictions Adult Alcohol Alcohol use Alcoholism Alcoholism - physiopathology Alcoholism - therapy Alcohols Attention Automation Brain Brain mapping Brain research Care and treatment Circuits Complications and side effects Cues Diagnosis Exposure Female Functional Laterality Functional magnetic resonance imaging Humans Magnetic brain stimulation Magnetic fields Magnetic Resonance Imaging Male Medical imaging Middle Aged Nerve Net - physiopathology Neuroimaging Neurosciences Paradigms Patients Prefrontal cortex Prefrontal Cortex - physiopathology Psychiatry Reinforcement Reward Systematic review Transcranial Magnetic Stimulation |
| title | The Impact of Accelerated Right Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Cue-Reactivity: An fMRI Study on Craving in Recently Detoxified Alcohol-Dependent Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T20%3A57%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Accelerated%20Right%20Prefrontal%20High-Frequency%20Repetitive%20Transcranial%20Magnetic%20Stimulation%20(rTMS)%20on%20Cue-Reactivity:%20An%20fMRI%20Study%20on%20Craving%20in%20Recently%20Detoxified%20Alcohol-Dependent%20Patients&rft.jtitle=PloS%20one&rft.au=Herremans,%20Sarah%20C&rft.date=2015-08-21&rft.volume=10&rft.issue=8&rft.spage=e0136182&rft.pages=e0136182-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0136182&rft_dat=%3Cgale_plos_%3EA426228314%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1708482714&rft_id=info:pmid/26295336&rft_galeid=A426228314&rft_doaj_id=oai_doaj_org_article_6bee504300aa4bab8def9fc28cb9a05c&rfr_iscdi=true |