Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

Doublecortin-like kinase 1 (Dclk1), a microtubule-associated kinase, marks the fifth lineage of intestinal epithelial cells called tuft cells that function as tumor stem cells in Apc mutant models of colon cancer. In order to determine the role of Dclk1 in dextran sulfate sodium (DSS) induced coloni...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134212
Hauptverfasser:	Qu, Dongfeng, Weygant, Nathaniel, May, Randal, Chandrakesan, Parthasarathy, Madhoun, Mohammad, Ali, Naushad, Sureban, Sripathi M, An, Guangyu, Schlosser, Michael J, Houchen, Courtney W
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adenomatous polyposis coli Analysis Animal models Animals Apoptosis - drug effects Apoptosis - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Chemokines Colitis Colitis - chemically induced Colitis - enzymology Colitis - genetics Colitis - pathology Colon Colon - drug effects Colon - metabolism Colon - pathology Colon cancer Colorectal cancer Cytokines Dextran Dextran sulfate Dextran Sulfate - adverse effects Dextrans Doublecortin protein Doublecortin-Like Kinases Drinking water Epithelial cells Epithelium Experiments Feces Gene Deletion Gene expression Health sciences Immunoblotting Inflammation Inflammatory bowel disease Inflammatory response Integrity Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Male Medicine Mice Molecular weight Pathogenesis Permeability Protein Serine-Threonine Kinases - deficiency Protein Serine-Threonine Kinases - genetics Rodents Sodium Stem cell transplantation Stem cells Stem Cells - drug effects Sulfates Veterans Wnt protein β-Catenin
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