Roles of TLR/MyD88/MAPK/NF-κB Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection

Enterococcus faecalis is a commensal bacterium residing in the gastrointestinal tract of mammals, but in certain situations it is also an opportunistic pathogen which can cause serious disease. Macrophages have been shown to play a critical role in controlling infections by commensal enterococci and...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0136947-e0136947
Hauptverfasser:	Zou, Jun, Shankar, Nathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial infections Bacterial proteins Bone marrow Cell activation Cell Line Colon Colon cancer Colonization Cytokines Cytokines - genetics Cytokines - metabolism Disease control Disease Models, Animal E coli Enterococcus faecalis Enterococcus faecalis - immunology Enterococcus faecalis - isolation & purification Enterococcus faecalis - pathogenicity Gastrointestinal tract Gene expression Genomic instability Gram-Positive Bacterial Infections - genetics Gram-Positive Bacterial Infections - immunology Gram-Positive Bacterial Infections - metabolism Gram-Positive Bacterial Infections - microbiology Health sciences IL-1β Infections Inflammation Inhibition Kinases Laboratory animals Macrophages Macrophages - immunology Macrophages - microbiology Macrophages - physiology MAP kinase MAP Kinase Signaling System Mice Molecular chains Molecular modelling MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB protein Opportunist infection Pathogenesis Pathogens Phagocytosis Pharmaceutical sciences Phenotypes Proteins Sepsis Signal transduction Signaling Stability Tumor necrosis factor-α
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