Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue

Streptococcus pneumoniae is a major cause of pneumonia, sepsis and meningitis. The pore-forming toxin pneumolysin is a key virulence factor of S. pneumoniae, which can be sensed by the NLRP3 inflammasome. Among the over 90 serotypes, serotype 1 pneumococci (particularly MLST306) have emerged across...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0137108-e0137108
Hauptverfasser:	Fatykhova, Diana, Rabes, Anne, Machnik, Christoph, Guruprasad, Kunchur, Pache, Florence, Berg, Johanna, Toennies, Mario, Bauer, Torsten T, Schneider, Paul, Schimek, Maria, Eggeling, Stephan, Mitchell, Timothy J, Mitchell, Andrea M, Hilker, Rolf, Hain, Torsten, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C, Opitz, Bastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - metabolism Behring, Emil Adolf von (1854-1917) Bioinformatics Caspase 1 - metabolism Cell culture Cytokines Development and progression Genetic aspects Genomes Genotype Gram-positive bacteria Hemolysis Humans Identification and classification IL-1β Immune response Immune system Infections Infectious diseases Inflammasomes Inflammasomes - metabolism Influenza Innate immunity Interleukin-1beta - biosynthesis Internal medicine Lung - cytology Lung - immunology Lung - metabolism Lung - microbiology Lungs Medicine Meningitis Mimicry Mortality Organ culture Pneumococcal infections Pneumolysin Pneumonia Pore formation Proteins Respiratory tract Sepsis Serotypes Species Specificity Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Streptococcus pneumoniae - metabolism Streptococcus pneumoniae - physiology Streptolysins - metabolism Surgery Thoracic surgery Toxins Viral infections Virulence Virulence (Microbiology) Virulence factors
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