Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study

Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin resulting in increased generation of angiotensin. Th...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0135905-e0135905
Hauptverfasser:	Rahgozar, Soheila, Amirian, Tayebeh, Qi, Miao, Shahshahan, Zahra, Entezar-E-Ghaem, Mansureh, Ghasemi Tehrani, Hatav, Miroliaei, Mehran, Krilis, Steven A, Giannakopoulos, Bill
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin Angiotensinogen Angiotensinogen - blood Angiotensinogen - chemistry Angiotensins Biological Assay - methods Biology Biomarkers Biomarkers - blood Care and treatment Case-Control Studies Comparative analysis Diagnosis Enzyme-Linked Immunosorbent Assay Female Free radicals Genetic aspects Gynecology Health risk assessment Homocysteine Hospitals Humans Hypertension Immunoassays Immunology Infectious diseases Obstetrics Oxidation-Reduction Oxidative Stress Patients Physiological aspects Placenta Plasma Plasma levels Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Preeclampsia Pregnancy Renin ROC Curve Sample size Sampling methods Science Womens health
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