Glypican Is a Modulator of Netrin-Mediated Axon Guidance

Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan,...

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Veröffentlicht in:	PLoS biology 2015-07, Vol.13 (7), p.e1002183-e1002183
Hauptverfasser:	Blanchette, Cassandra R, Perrat, Paola N, Thackeray, Andrea, Bénard, Claire Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - physiology Caenorhabditis elegans Caenorhabditis elegans Proteins - metabolism Defects Experiments Glypicans - metabolism Growth factors Heparan sulfate Migration Nematodes Nerve Tissue Proteins - metabolism Nervous system Netrins Proteins Signal Transduction Syndecans - metabolism
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