Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder

Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors. A major roadblock for drug development for autism is the lack of robust behavioral signatures predictive of clinical efficacy. To address this is...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134572-e0134572
Hauptverfasser:	Brunner, Daniela, Kabitzke, Patricia, He, Dansha, Cox, Kimberly, Thiede, Lucinda, Hanania, Taleen, Sabath, Emily, Alexandrov, Vadim, Saxe, Michael, Peles, Elior, Mills, Alea, Spooren, Will, Ghosh, Anirvan, Feliciano, Pamela, Benedetti, Marta, Luo Clayton, Alice, Biemans, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Newborn Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - physiopathology Behavior Behavior, Animal - physiology Brain research Chromosome 16 Chromosome deletion Chromosomes, Mammalian - genetics Cognition - physiology Cognitive ability Communities Computer vision Developmental stages Disease Models, Animal Drug development Estrus Female Gait Gene deletion Genes Genetic engineering Humans Hyperactivity Laboratory animals Male Membrane Proteins - genetics Mice Mouse devices Mutation Nerve Tissue Proteins - genetics Neurodevelopmental disorders Open-field behavior Phenotypes Replicating Replication Robustness Rodents Sequence Deletion Signal transduction Urine Validity Vision systems Vocalization behavior Vocalization, Animal - physiology
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