Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses
The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that virus-specific CD4 T cells were responsible for much of the tissue destruction and clinical disease. [...]the early 2000s, coronaviruses were not co...
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| Veröffentlicht in: | PLoS pathogens 2015-07, Vol.11 (7), p.e1005023-e1005023 |
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| container_title | PLoS pathogens |
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| creator | Perlman, Stanley |
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The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that virus-specific CD4 T cells were responsible for much of the tissue destruction and clinical disease. [...]the early 2000s, coronaviruses were not considered important human pathogens. |
| doi_str_mv | 10.1371/journal.ppat.1005023 |
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The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that virus-specific CD4 T cells were responsible for much of the tissue destruction and clinical disease. [...]the early 2000s, coronaviruses were not considered important human pathogens.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1005023</identifier><identifier>PMID: 26172373</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biomedical research ; Biomedical Research - history ; Coronaviridae ; Coronaviridae Infections ; Funding ; History, 20th Century ; History, 21st Century ; Humans ; Infections ; Infectious diseases ; Lymphocytes ; Molecular biology ; Molecular Biology - history ; Research Matters ; Respiratory diseases ; Rodents ; Virology</subject><ispartof>PLoS pathogens, 2015-07, Vol.11 (7), p.e1005023-e1005023</ispartof><rights>2015 Stanley Perlman 2015 Stanley Perlman</rights><rights>2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Perlman S (2015) Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. PLoS Pathog 11(7): e1005023. doi:10.1371/journal.ppat.1005023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b99f4b6c2fdca246142aab56d667d7eabd500485cc5b7ad6ddeb97632c9643c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501819/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501819/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26172373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perlman, Stanley</creatorcontrib><title>Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>
The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that virus-specific CD4 T cells were responsible for much of the tissue destruction and clinical disease. [...]the early 2000s, coronaviruses were not considered important human pathogens.</description><subject>Animals</subject><subject>Biomedical research</subject><subject>Biomedical Research - history</subject><subject>Coronaviridae</subject><subject>Coronaviridae Infections</subject><subject>Funding</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lymphocytes</subject><subject>Molecular biology</subject><subject>Molecular Biology - history</subject><subject>Research Matters</subject><subject>Respiratory diseases</subject><subject>Rodents</subject><subject>Virology</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVUktvEzEQXiEQLYV_gMBHLgl-e80BqQ2PFhWBoHC1xo9NHG3Wwd6NtDd-OhuSVu3JY_t7zIy-qnpJ8JwwRd6u05A7aOfbLfRzgrHAlD2qTokQbKaY4o_v1SfVs1LWGHPCiHxanVBJFGWKnVZ_f4QSILsV-pDjLnTIjmgx5JhK7Md36GYV0Je9URhRk9MGXUCJDn1NbXBDCxldxNSm5Yig8-h3zIdLn9DPfvAxFJQadDlsoEPfoV-lZegm9iLl1MEu5qGE8rx60kBbwovjeVb9-vTxZnE5u_72-Wpxfj1zXNf9zGrdcCsdbbwDyiXhFMAK6aVUXgWwXkzj1cI5YRV46X2wWklGnZacOcHOqtcH3W2bijkurxiiMGeEUVFPiKsDwidYm22OG8ijSRDN_4eUlwZyH10bjOYNxtI2VmPNKRe2FswTIm2tsAbNJ633R7fBboJ3oesztA9EH_50cWWWaWe4wKQmehJ4cxTI6c8QSm82sbjQttCFNEx9S60ooQLLCcoPUJdTKTk0dzYEm31Ubqc1-6iYY1Qm2qv7Ld6RbrPB_gGE_L8l</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Perlman, Stanley</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150701</creationdate><title>Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses</title><author>Perlman, Stanley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b99f4b6c2fdca246142aab56d667d7eabd500485cc5b7ad6ddeb97632c9643c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biomedical research</topic><topic>Biomedical Research - history</topic><topic>Coronaviridae</topic><topic>Coronaviridae Infections</topic><topic>Funding</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lymphocytes</topic><topic>Molecular biology</topic><topic>Molecular Biology - history</topic><topic>Research Matters</topic><topic>Respiratory diseases</topic><topic>Rodents</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perlman, Stanley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perlman, Stanley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>11</volume><issue>7</issue><spage>e1005023</spage><epage>e1005023</epage><pages>e1005023-e1005023</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>
The second major discovery was that another type of T cell, the CD4 T cell, was the major factor in host tissue damage in MHV-infected mice, and that virus-specific CD4 T cells were responsible for much of the tissue destruction and clinical disease. [...]the early 2000s, coronaviruses were not considered important human pathogens.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26172373</pmid><doi>10.1371/journal.ppat.1005023</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1553-7374 1553-7366 1553-7374 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biomedical research Biomedical Research - history Coronaviridae Coronaviridae Infections Funding History, 20th Century History, 21st Century Humans Infections Infectious diseases Lymphocytes Molecular biology Molecular Biology - history Research Matters Respiratory diseases Rodents Virology |
| title | Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses |
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