LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice

The LKB1 gene, which encodes a serine/threonine kinase, was discovered to play crucial roles in cell differentiation, proliferation, and the establishment of cell polarity. In our study, LKB1 conditional knockout mice (Atoh1-LKB1-/- mice) were generated to investigate LKB1 function in the inner ear....

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0135841-e0135841
Hauptverfasser:	Men, Yuqin, Zhang, Aizhen, Li, Haixiang, Zhang, Tingting, Jin, Yecheng, Li, Huashun, Zhang, Jian, Gao, Jiangang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Auditory system Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Binding Brain stem Bundles Bundling Cell differentiation Core loss Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeleton Cytoskeleton - genetics Cytoskeleton - metabolism Developmental biology Differentiation (biology) Ear Ears & hearing Ethics Ezrin Hair Hair cells Hair Cells, Auditory, Inner - cytology Hair Cells, Auditory, Inner - metabolism Hearing loss Inner ear Jian Zhang Life sciences LKB1 protein Math1 protein Medicine Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Microfilament Proteins - genetics Microfilament Proteins - metabolism Moesin Muscle proteins Mutation Neurosciences Otoacoustic emissions Phosphorylation Polarity Protein binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proteins Radixin Signal transduction Stem cells Stereocilia - metabolism Threonine
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