The Role of Liver in Determining Serum Colon-Derived Uremic Solutes

Evidence has shown that indoxyl sulfate (IS) and p-cresyl sulfate (PCS) may be alternative predictors of clinical outcomes in chronic kidney disease (CKD). Both toxins are derived from the gastrointestinal tract and metabolised in the liver. However, it is unclear whether the liver affects the produ...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134590-e0134590
Hauptverfasser:	Lin, Cheng-Jui, Liou, Tai-Cherng, Pan, Chi-Feng, Wu, Pei-Chen, Sun, Fang-Ju, Liu, Hsuan-Liang, Chen, Han-Hsiang, Wu, Chih-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Animals Chronic kidney failure Cirrhosis Cohort Studies Colon Colon - metabolism Community colleges Cresols - blood Cresols - urine Disease Models, Animal Female Fibrosis Gastroenterology Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - metabolism Hospitals Humans Indican - blood Indican - urine Internal medicine Kidney - metabolism Kidney diseases Kidneys Linear Models Liver Liver - physiology Liver cirrhosis Liver Cirrhosis - metabolism Liver diseases Male Medicine Middle Aged Mortality Multivariate Analysis Nephrology Patients Peritoneal dialysis Proteins Rats Rats, Sprague-Dawley Regression analysis Renal Insufficiency, Chronic - metabolism Solutes Sulfate Sulfates Sulfuric Acid Esters - blood Sulfuric Acid Esters - urine Toxins Treatment Outcome Uremia - blood Urine
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