MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction

Myocardial infarction (MI) is a severe coronary artery disease and a leading cause of mortality and morbidity worldwide. However, the molecular mechanisms of MI have yet to be fully elucidated. In this study, we compiled MI-related genes, MI-related microRNAs (miRNAs) and known human transcription f...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0135339-e0135339
Hauptverfasser:	Zhang, Guangde, Shi, Hongbo, Wang, Lin, Zhou, Meng, Wang, Zhenzhen, Liu, Xiaoxia, Cheng, Liang, Li, Weimin, Li, Xueqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Bioinformatics Cardiology Cardiovascular disease Computational Biology Coronary artery Coronary artery disease ESR1 protein Feedback, Physiological Fibrosis Gene expression Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Genes Health aspects Heart attack Heart attacks Heart diseases Hospitals Humans Literature reviews MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Models, Genetic Modules Molecular chains Molecular modelling Morbidity Mortality Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Network analysis Network reliability Pathogenesis Proteins Regulators Regulatory mechanisms (biology) Reproducibility of Results Ribonucleic acid RNA Rodents Science Signal Transduction Sp1 protein Stem cells Therapeutic applications Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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