Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?
The identification of a predisposition toward malignant hyperthermia (MH) as a risk factor for exertional heat stroke (EHS) remains a matter of debate. Such a predisposition indicates a causal role for MH susceptibility (MHS) after EHS in certain national recommendations and has led to the use of an...
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| creator | Sagui, Emmanuel Montigon, Coline Abriat, Amandine Jouvion, Arnaud Duron-Martinaud, Sandrine Canini, Frédéric Zagnoli, Fabien Bendahan, David Figarella-Branger, Dominique Brégigeon, Michel Brosset, Christian |
| description | The identification of a predisposition toward malignant hyperthermia (MH) as a risk factor for exertional heat stroke (EHS) remains a matter of debate. Such a predisposition indicates a causal role for MH susceptibility (MHS) after EHS in certain national recommendations and has led to the use of an in vitro contracture test (IVCT) to identify the MHS trait in selected or unselected EHS patients. The aim of this study was to determine whether the MHS trait is associated with EHS.
EHS subjects in the French Armed Forces were routinely examined for MHS after experiencing an EHS episode. This retrospective study compared the features of IVCT-diagnosed MHS (iMHS) EHS subjects with those of MH-normal EHS patients and MH patients during the 2004-2010 period. MHS status was assessed using the European protocol.
During the study period, 466 subjects (median age 25 years; 31 women) underwent MHS status investigation following an EHS episode. None of the subjects reported previous MH events. An IVCT was performed in 454 cases and was diagnostic of MHS in 45.6% of the study population, of MH susceptibility to halothane in 18.5%, of MH susceptibility to caffeine in 9.9%, and of MH susceptibility to halothane and caffeine in 17.2%. There were no differences in the clinical features, biological features or outcomes of iMHS EHS subjects compared with those of MH-normal or caffeine or halothane MHS subjects without known prior EHS episode. The recurrence rate was 12.7% and was not associated with MH status or any clinical or biological features. iMHS EHS patients exhibited a significantly less informative IVCT response than MH patients.
The unexpected high prevalence of the MHS trait after EHS suggested a latent disturbance of calcium homeostasis that accounted for the positive IVCT results. This study did not determine whether EHS patients have an increased risk of MH, and it could not determine whether MH susceptibility is a risk factor for EHS. |
| doi_str_mv | 10.1371/journal.pone.0135496 |
| format | Article |
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EHS subjects in the French Armed Forces were routinely examined for MHS after experiencing an EHS episode. This retrospective study compared the features of IVCT-diagnosed MHS (iMHS) EHS subjects with those of MH-normal EHS patients and MH patients during the 2004-2010 period. MHS status was assessed using the European protocol.
During the study period, 466 subjects (median age 25 years; 31 women) underwent MHS status investigation following an EHS episode. None of the subjects reported previous MH events. An IVCT was performed in 454 cases and was diagnostic of MHS in 45.6% of the study population, of MH susceptibility to halothane in 18.5%, of MH susceptibility to caffeine in 9.9%, and of MH susceptibility to halothane and caffeine in 17.2%. There were no differences in the clinical features, biological features or outcomes of iMHS EHS subjects compared with those of MH-normal or caffeine or halothane MHS subjects without known prior EHS episode. The recurrence rate was 12.7% and was not associated with MH status or any clinical or biological features. iMHS EHS patients exhibited a significantly less informative IVCT response than MH patients.
The unexpected high prevalence of the MHS trait after EHS suggested a latent disturbance of calcium homeostasis that accounted for the positive IVCT results. This study did not determine whether EHS patients have an increased risk of MH, and it could not determine whether MH susceptibility is a risk factor for EHS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0135496</identifier><identifier>PMID: 26258863</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Anesthesiology ; Anesthetics, Inhalation - pharmacology ; Armed forces ; Caffeine ; Caffeine - pharmacology ; Calcium ; Calcium homeostasis ; Contracture - chemically induced ; Contracture - physiopathology ; Diagnostic systems ; Disease Susceptibility ; Exercise ; Female ; Fever ; Halothane ; Halothane - pharmacology ; Heat stroke ; Heat Stroke - diagnosis ; Heat Stroke - physiopathology ; Heatstroke ; Homeostasis ; Hospitals ; Human health and pathology ; Humans ; Hyperthermia ; Illnesses ; In vitro methods and tests ; Life Sciences ; Male ; Malignant hyperthermia ; Malignant Hyperthermia - diagnosis ; Malignant Hyperthermia - physiopathology ; Metabolism ; Military ; Muscle Contraction - drug effects ; Muscle, Skeletal - drug effects ; Neuromuscular diseases ; Patients ; Physical fitness ; Population studies ; Retrospective Studies ; Risk Factors ; Spectrum analysis ; Sports medicine ; Stroke</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0135496-e0135496</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Sagui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2015 Sagui et al 2015 Sagui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-e5526e83e9a6547375cf19717c64b64e52d861b33474eb9f57784660a30f3c373</citedby><cites>FETCH-LOGICAL-c726t-e5526e83e9a6547375cf19717c64b64e52d861b33474eb9f57784660a30f3c373</cites><orcidid>0000-0002-3604-887X ; 0000-0002-1502-0958 ; 0000-0002-2890-8470 ; 0000-0002-2574-2153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530942/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530942/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26258863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-01198632$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sagui, Emmanuel</creatorcontrib><creatorcontrib>Montigon, Coline</creatorcontrib><creatorcontrib>Abriat, Amandine</creatorcontrib><creatorcontrib>Jouvion, Arnaud</creatorcontrib><creatorcontrib>Duron-Martinaud, Sandrine</creatorcontrib><creatorcontrib>Canini, Frédéric</creatorcontrib><creatorcontrib>Zagnoli, Fabien</creatorcontrib><creatorcontrib>Bendahan, David</creatorcontrib><creatorcontrib>Figarella-Branger, Dominique</creatorcontrib><creatorcontrib>Brégigeon, Michel</creatorcontrib><creatorcontrib>Brosset, Christian</creatorcontrib><title>Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The identification of a predisposition toward malignant hyperthermia (MH) as a risk factor for exertional heat stroke (EHS) remains a matter of debate. Such a predisposition indicates a causal role for MH susceptibility (MHS) after EHS in certain national recommendations and has led to the use of an in vitro contracture test (IVCT) to identify the MHS trait in selected or unselected EHS patients. The aim of this study was to determine whether the MHS trait is associated with EHS.
EHS subjects in the French Armed Forces were routinely examined for MHS after experiencing an EHS episode. This retrospective study compared the features of IVCT-diagnosed MHS (iMHS) EHS subjects with those of MH-normal EHS patients and MH patients during the 2004-2010 period. MHS status was assessed using the European protocol.
During the study period, 466 subjects (median age 25 years; 31 women) underwent MHS status investigation following an EHS episode. None of the subjects reported previous MH events. An IVCT was performed in 454 cases and was diagnostic of MHS in 45.6% of the study population, of MH susceptibility to halothane in 18.5%, of MH susceptibility to caffeine in 9.9%, and of MH susceptibility to halothane and caffeine in 17.2%. There were no differences in the clinical features, biological features or outcomes of iMHS EHS subjects compared with those of MH-normal or caffeine or halothane MHS subjects without known prior EHS episode. The recurrence rate was 12.7% and was not associated with MH status or any clinical or biological features. iMHS EHS patients exhibited a significantly less informative IVCT response than MH patients.
The unexpected high prevalence of the MHS trait after EHS suggested a latent disturbance of calcium homeostasis that accounted for the positive IVCT results. This study did not determine whether EHS patients have an increased risk of MH, and it could not determine whether MH susceptibility is a risk factor for EHS.</description><subject>Adult</subject><subject>Anesthesiology</subject><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Armed forces</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Calcium</subject><subject>Calcium homeostasis</subject><subject>Contracture - chemically induced</subject><subject>Contracture - physiopathology</subject><subject>Diagnostic systems</subject><subject>Disease Susceptibility</subject><subject>Exercise</subject><subject>Female</subject><subject>Fever</subject><subject>Halothane</subject><subject>Halothane - pharmacology</subject><subject>Heat stroke</subject><subject>Heat Stroke - diagnosis</subject><subject>Heat Stroke - physiopathology</subject><subject>Heatstroke</subject><subject>Homeostasis</subject><subject>Hospitals</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hyperthermia</subject><subject>Illnesses</subject><subject>In vitro methods and tests</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Malignant hyperthermia</subject><subject>Malignant Hyperthermia - diagnosis</subject><subject>Malignant Hyperthermia - physiopathology</subject><subject>Metabolism</subject><subject>Military</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Neuromuscular diseases</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Population studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Spectrum analysis</subject><subject>Sports medicine</subject><subject>Stroke</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01r20AQhkVpadK0_6C0gkJpDnZ3tV_SpcWEtjEYAv06FZaVPLLWkbSOdpXG_77jWAlWyKHoIDF65p2dd2ei6DUlU8oU_bh2fdeaerpxLUwJZYJn8kl0TDOWTGRC2NOD76PohfdrQgRLpXweHSUyEWkq2XH0Z-7jUEEHsYlr217GOYS_AG0MN9AF67BCXIEJsQ-du0SqXca-9wVsgs1tbcM2Di5uTG1XrWlDXG03mIeCjTWfX0bPSlN7eDW8T6JfX7_8PDufLC6-zc9mi0mhEhkmIEQiIWWQGSm4YkoUJc0UVYXkueQgkmUqac4YVxzyrBRKpVxKYhgpWcEUO4ne7nU3tfN6MMZrqkiScsaYRGK-J5bOrPWms43pttoZq28Drltpg-0WNWhKiywXiUCzcp5lMicmlcYQAA48z3PU-jRU6_MGlgW0oTP1SHT8p7WVXrlrzQUjGU9Q4HQvUD1IO58t9C5GKM3wdpJriuyHoVjnrnrwQTcW3a9r04Lrb3vEYVB4UETfPUAfd2KgVgabtW3p8IzFTlTPOHZNU5YIpKaPUPgsobEFTlxpMT5KOB0lIBPgJqxM772e__j-_-zF7zH7_oDFSaxD5V3d70bTj0G-B4vOed9Bee8sJXq3MHdu6N3C6GFhMO3N4WXeJ91tCPsH5dgOVA</recordid><startdate>20150810</startdate><enddate>20150810</enddate><creator>Sagui, Emmanuel</creator><creator>Montigon, Coline</creator><creator>Abriat, Amandine</creator><creator>Jouvion, Arnaud</creator><creator>Duron-Martinaud, Sandrine</creator><creator>Canini, Frédéric</creator><creator>Zagnoli, Fabien</creator><creator>Bendahan, David</creator><creator>Figarella-Branger, Dominique</creator><creator>Brégigeon, Michel</creator><creator>Brosset, Christian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3604-887X</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-2890-8470</orcidid><orcidid>https://orcid.org/0000-0002-2574-2153</orcidid></search><sort><creationdate>20150810</creationdate><title>Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?</title><author>Sagui, Emmanuel ; Montigon, Coline ; Abriat, Amandine ; Jouvion, Arnaud ; Duron-Martinaud, Sandrine ; Canini, Frédéric ; Zagnoli, Fabien ; Bendahan, David ; Figarella-Branger, Dominique ; Brégigeon, Michel ; Brosset, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-e5526e83e9a6547375cf19717c64b64e52d861b33474eb9f57784660a30f3c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Anesthesiology</topic><topic>Anesthetics, Inhalation - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagui, Emmanuel</au><au>Montigon, Coline</au><au>Abriat, Amandine</au><au>Jouvion, Arnaud</au><au>Duron-Martinaud, Sandrine</au><au>Canini, Frédéric</au><au>Zagnoli, Fabien</au><au>Bendahan, David</au><au>Figarella-Branger, Dominique</au><au>Brégigeon, Michel</au><au>Brosset, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-10</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0135496</spage><epage>e0135496</epage><pages>e0135496-e0135496</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The identification of a predisposition toward malignant hyperthermia (MH) as a risk factor for exertional heat stroke (EHS) remains a matter of debate. Such a predisposition indicates a causal role for MH susceptibility (MHS) after EHS in certain national recommendations and has led to the use of an in vitro contracture test (IVCT) to identify the MHS trait in selected or unselected EHS patients. The aim of this study was to determine whether the MHS trait is associated with EHS.
EHS subjects in the French Armed Forces were routinely examined for MHS after experiencing an EHS episode. This retrospective study compared the features of IVCT-diagnosed MHS (iMHS) EHS subjects with those of MH-normal EHS patients and MH patients during the 2004-2010 period. MHS status was assessed using the European protocol.
During the study period, 466 subjects (median age 25 years; 31 women) underwent MHS status investigation following an EHS episode. None of the subjects reported previous MH events. An IVCT was performed in 454 cases and was diagnostic of MHS in 45.6% of the study population, of MH susceptibility to halothane in 18.5%, of MH susceptibility to caffeine in 9.9%, and of MH susceptibility to halothane and caffeine in 17.2%. There were no differences in the clinical features, biological features or outcomes of iMHS EHS subjects compared with those of MH-normal or caffeine or halothane MHS subjects without known prior EHS episode. The recurrence rate was 12.7% and was not associated with MH status or any clinical or biological features. iMHS EHS patients exhibited a significantly less informative IVCT response than MH patients.
The unexpected high prevalence of the MHS trait after EHS suggested a latent disturbance of calcium homeostasis that accounted for the positive IVCT results. This study did not determine whether EHS patients have an increased risk of MH, and it could not determine whether MH susceptibility is a risk factor for EHS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26258863</pmid><doi>10.1371/journal.pone.0135496</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3604-887X</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-2890-8470</orcidid><orcidid>https://orcid.org/0000-0002-2574-2153</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-08, Vol.10 (8), p.e0135496-e0135496 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1702843336 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Anesthesiology Anesthetics, Inhalation - pharmacology Armed forces Caffeine Caffeine - pharmacology Calcium Calcium homeostasis Contracture - chemically induced Contracture - physiopathology Diagnostic systems Disease Susceptibility Exercise Female Fever Halothane Halothane - pharmacology Heat stroke Heat Stroke - diagnosis Heat Stroke - physiopathology Heatstroke Homeostasis Hospitals Human health and pathology Humans Hyperthermia Illnesses In vitro methods and tests Life Sciences Male Malignant hyperthermia Malignant Hyperthermia - diagnosis Malignant Hyperthermia - physiopathology Metabolism Military Muscle Contraction - drug effects Muscle, Skeletal - drug effects Neuromuscular diseases Patients Physical fitness Population studies Retrospective Studies Risk Factors Spectrum analysis Sports medicine Stroke |
| title | Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T11%3A45%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20there%20a%20link%20between%20exertional%20heat%20stroke%20and%20susceptibility%20to%20malignant%20hyperthermia?&rft.jtitle=PloS%20one&rft.au=Sagui,%20Emmanuel&rft.date=2015-08-10&rft.volume=10&rft.issue=8&rft.spage=e0135496&rft.epage=e0135496&rft.pages=e0135496-e0135496&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0135496&rft_dat=%3Cgale_plos_%3EA425018325%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1702843336&rft_id=info:pmid/26258863&rft_galeid=A425018325&rft_doaj_id=oai_doaj_org_article_11c9b525053b4996b0a86aa0ee4e4bbb&rfr_iscdi=true |