Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

Coronary artery disease (CAD) is a complex disease and the leading cause of death in the world. Populations of different ancestry do not always share the same risk markers. Natural selective processes may be the cause of some of the population differences detected for specific risk mutations. In thi...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134840-e0134840
Hauptverfasser:	Zanetti, Daniela, Carreras-Torres, Robert, Esteban, Esther, Via, Marc, Moral, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Asian Continental Ancestry Group - genetics Biodiversity Biology Cardiovascular disease Care and treatment Chromosomes, Human, Pair 10 - genetics Chromosomes, Human, Pair 9 - genetics Coronary artery Coronary artery disease Coronary Artery Disease - genetics Coronary diseases Coronary heart disease Coronary vessels Demography Development and progression Diabetes European Continental Ancestry Group - genetics Factors de risc en les malalties Gene Frequency - genetics Genes Genetic aspects Genetic diversity Genetic Loci Genetic Predisposition to Disease Genetic variability Genetic Variation Genetics Genetics, Population Genome, Human Genomes Genomics Geography Health risks Heart attacks Heart diseases Heterozygote Human populations Humans Hypertension Linkage Disequilibrium - genetics Malalties coronàries Markers Minority & ethnic groups Mutation Natural selection Polymorphism, Single Nucleotide - genetics Population Populations Positive selection Principal Component Analysis Quality Control Risk Risk Factors Risk factors in diseases Selecció natural Selection, Genetic Single nucleotide polymorphisms Single-nucleotide polymorphism Surveys
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