IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells

Dengue hemorrhagic fever (DHF)/Dengue shock syndrome (DSS) is a fatal infectious disease that demands an effective treatment. Interferon (IFN)-stimulated genes (ISGs) induced by dengue virus (DENV) exert antiviral effects. Among ISGs, IFN-α inducible gene 6 (IFI6) was increased in DENV infected huma...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0132743-e0132743
Hauptverfasser:	Qi, Yiming, Li, Ying, Zhang, Yingke, Zhang, Lin, Wang, Zilian, Zhang, Xuzhi, Gui, Lian, Huang, Junqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Bax protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological response modifiers Biotechnology Care and treatment Caspase Caspase-3 Caspase-9 Cell Line Cell lines Dengue - virology Dengue fever Dengue hemorrhagic fever Dengue Virus Depolarization Diagnosis DNA microarrays Down-Regulation Endothelial cells Endothelial Cells - metabolism Endothelial Cells - virology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - virology Fever Fluorescence Genomics Health aspects Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - virology Humans Incubation Infections Infectious diseases Interferon Kinases Medical treatment Membrane potential Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Protein X Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Risk factors Signal Transduction - genetics Tropical diseases Up-Regulation Vector-borne diseases Viral diseases Viruses X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism XIAP protein α-Interferon
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