Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus
Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal netwo...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-08, Vol.10 (8), p.e0132676-e0132676 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0132676 |
|---|---|
| container_issue | 8 |
| container_start_page | e0132676 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Carasatorre, Mariana Ochoa-Alvarez, Adrian Velázquez-Campos, Giovanna Lozano-Flores, Carlos Ramírez-Amaya, Víctor Díaz-Cintra, Sofía Y |
| description | Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal network. We first tested this by using the the delayed non-matching to place task (DNMP), in animals that had been previously trained on the water maze (WM) and found that these animals, as well as animals treated as swim controls (SC), performed better than home cage control animals the DNMP task. The "catFISH" imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training. Moreover, these behavioral treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the distal CA3, we found evidence of structural synaptic plasticity that likely includes MF expansion. Finally, the measures of hippocampal network coding obtained with catFISH correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing in the hippocampus. |
| doi_str_mv | 10.1371/journal.pone.0132676 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1701896263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A432692679</galeid><doaj_id>oai_doaj_org_article_3ccf509121ac47c39bfa788e3177bdc5</doaj_id><sourcerecordid>A432692679</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-1abb51a223b526a7a8f441c5996b97a179815148fa22e93d2d0011f08cc8590b3</originalsourceid><addsrcrecordid>eNqNk99u0zAUxiMEYmPwBggiISG4aPGfxIlvkKZqsEiThlbg1jpxnNZTYgc7GesT8Nq4bVY1aBcoF47s3_cdn-Nzoug1RnNMM_zp1g7OQDPvrFFzhClhGXsSnWJOyYwRRJ8e_Z9EL7y_RSilOWPPoxPCSJKkCT-N_lzqrrMS2g6aeLkx0PVaxhf3HRivrYkLUw1SVXG5iZcd9DpQ4VA5rYxUsTbxDfQ-XljnVAO98vFv3a_jou2cvQuywtTWtUEXrL45K5X32qy2un6t4kPswb-MntXQePVqXM-iH18uvi8uZ1fXX4vF-dVMMk76GYayTDEQQsuUMMggr5MEy5RzVvIMcMZznOIkrwOiOK1IhRDGNcqlzFOOSnoWvd37do31YqyhFzhDOOeMMBqIYk9UFm5F53QLbiMsaLHbsG4lwIUiNUpQKesUcUwwyCSTlJc1ZHmuKM6yspJp8Po8RhvKVlVSmd5BMzGdnhi9Fit7J5KQHdtd5sNo4OyvQfletNpL1TRglB129yYsRYgmAX33D_p4diO1gpCADs8T4sqtqThPQg_x0EY8UPNHqPBVqtUyNFytw_5E8HEiCEyv7vsVDN6LYnnz_-z1zyn7_ohdK2j6tbfNsG0oPwWTPSid9d6p-lBkjMR2Xh6qIbbzIsZ5CbI3xw90ED0MCP0LepYRZg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1701896263</pqid></control><display><type>article</type><title>Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Carasatorre, Mariana ; Ochoa-Alvarez, Adrian ; Velázquez-Campos, Giovanna ; Lozano-Flores, Carlos ; Ramírez-Amaya, Víctor ; Díaz-Cintra, Sofía Y</creator><creatorcontrib>Carasatorre, Mariana ; Ochoa-Alvarez, Adrian ; Velázquez-Campos, Giovanna ; Lozano-Flores, Carlos ; Ramírez-Amaya, Víctor ; Díaz-Cintra, Sofía Y</creatorcontrib><description>Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal network. We first tested this by using the the delayed non-matching to place task (DNMP), in animals that had been previously trained on the water maze (WM) and found that these animals, as well as animals treated as swim controls (SC), performed better than home cage control animals the DNMP task. The "catFISH" imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training. Moreover, these behavioral treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the distal CA3, we found evidence of structural synaptic plasticity that likely includes MF expansion. Finally, the measures of hippocampal network coding obtained with catFISH correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing in the hippocampus.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0132676</identifier><identifier>PMID: 26244549</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Behavior, Animal - physiology ; Behavioral plasticity ; Catfish ; Coding ; Data processing ; Exercise ; Expansion ; Gene expression ; Hippocampal plasticity ; Hippocampus ; Hippocampus (Brain) ; Hippocampus - physiology ; Information processing ; Male ; Maze Learning - physiology ; Memory ; Mossy Fibers, Hippocampal - physiology ; Network reliability ; Neural coding ; Neuronal Plasticity - physiology ; Neurophysiology ; Overtraining ; Physiological aspects ; Plasticity ; Rats ; Rats, Wistar ; Rodents ; Separation ; Spatial Behavior - physiology ; Spatial data ; Spatial Memory - physiology ; Staining ; Synapses - physiology ; Synaptic plasticity ; Synaptic Transmission - physiology ; Synaptic vesicles ; Synaptophysin</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0132676-e0132676</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Carasatorre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Carasatorre et al 2015 Carasatorre et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1abb51a223b526a7a8f441c5996b97a179815148fa22e93d2d0011f08cc8590b3</citedby><cites>FETCH-LOGICAL-c692t-1abb51a223b526a7a8f441c5996b97a179815148fa22e93d2d0011f08cc8590b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526663/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526663/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26244549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carasatorre, Mariana</creatorcontrib><creatorcontrib>Ochoa-Alvarez, Adrian</creatorcontrib><creatorcontrib>Velázquez-Campos, Giovanna</creatorcontrib><creatorcontrib>Lozano-Flores, Carlos</creatorcontrib><creatorcontrib>Ramírez-Amaya, Víctor</creatorcontrib><creatorcontrib>Díaz-Cintra, Sofía Y</creatorcontrib><title>Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal network. We first tested this by using the the delayed non-matching to place task (DNMP), in animals that had been previously trained on the water maze (WM) and found that these animals, as well as animals treated as swim controls (SC), performed better than home cage control animals the DNMP task. The "catFISH" imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training. Moreover, these behavioral treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the distal CA3, we found evidence of structural synaptic plasticity that likely includes MF expansion. Finally, the measures of hippocampal network coding obtained with catFISH correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing in the hippocampus.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral plasticity</subject><subject>Catfish</subject><subject>Coding</subject><subject>Data processing</subject><subject>Exercise</subject><subject>Expansion</subject><subject>Gene expression</subject><subject>Hippocampal plasticity</subject><subject>Hippocampus</subject><subject>Hippocampus (Brain)</subject><subject>Hippocampus - physiology</subject><subject>Information processing</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory</subject><subject>Mossy Fibers, Hippocampal - physiology</subject><subject>Network reliability</subject><subject>Neural coding</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurophysiology</subject><subject>Overtraining</subject><subject>Physiological aspects</subject><subject>Plasticity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Separation</subject><subject>Spatial Behavior - physiology</subject><subject>Spatial data</subject><subject>Spatial Memory - physiology</subject><subject>Staining</subject><subject>Synapses - physiology</subject><subject>Synaptic plasticity</subject><subject>Synaptic Transmission - physiology</subject><subject>Synaptic vesicles</subject><subject>Synaptophysin</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYmPwBggiISG4aPGfxIlvkKZqsEiThlbg1jpxnNZTYgc7GesT8Nq4bVY1aBcoF47s3_cdn-Nzoug1RnNMM_zp1g7OQDPvrFFzhClhGXsSnWJOyYwRRJ8e_Z9EL7y_RSilOWPPoxPCSJKkCT-N_lzqrrMS2g6aeLkx0PVaxhf3HRivrYkLUw1SVXG5iZcd9DpQ4VA5rYxUsTbxDfQ-XljnVAO98vFv3a_jou2cvQuywtTWtUEXrL45K5X32qy2un6t4kPswb-MntXQePVqXM-iH18uvi8uZ1fXX4vF-dVMMk76GYayTDEQQsuUMMggr5MEy5RzVvIMcMZznOIkrwOiOK1IhRDGNcqlzFOOSnoWvd37do31YqyhFzhDOOeMMBqIYk9UFm5F53QLbiMsaLHbsG4lwIUiNUpQKesUcUwwyCSTlJc1ZHmuKM6yspJp8Po8RhvKVlVSmd5BMzGdnhi9Fit7J5KQHdtd5sNo4OyvQfletNpL1TRglB129yYsRYgmAX33D_p4diO1gpCADs8T4sqtqThPQg_x0EY8UPNHqPBVqtUyNFytw_5E8HEiCEyv7vsVDN6LYnnz_-z1zyn7_ohdK2j6tbfNsG0oPwWTPSid9d6p-lBkjMR2Xh6qIbbzIsZ5CbI3xw90ED0MCP0LepYRZg</recordid><startdate>20150805</startdate><enddate>20150805</enddate><creator>Carasatorre, Mariana</creator><creator>Ochoa-Alvarez, Adrian</creator><creator>Velázquez-Campos, Giovanna</creator><creator>Lozano-Flores, Carlos</creator><creator>Ramírez-Amaya, Víctor</creator><creator>Díaz-Cintra, Sofía Y</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150805</creationdate><title>Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus</title><author>Carasatorre, Mariana ; Ochoa-Alvarez, Adrian ; Velázquez-Campos, Giovanna ; Lozano-Flores, Carlos ; Ramírez-Amaya, Víctor ; Díaz-Cintra, Sofía Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1abb51a223b526a7a8f441c5996b97a179815148fa22e93d2d0011f08cc8590b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral plasticity</topic><topic>Catfish</topic><topic>Coding</topic><topic>Data processing</topic><topic>Exercise</topic><topic>Expansion</topic><topic>Gene expression</topic><topic>Hippocampal plasticity</topic><topic>Hippocampus</topic><topic>Hippocampus (Brain)</topic><topic>Hippocampus - physiology</topic><topic>Information processing</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory</topic><topic>Mossy Fibers, Hippocampal - physiology</topic><topic>Network reliability</topic><topic>Neural coding</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurophysiology</topic><topic>Overtraining</topic><topic>Physiological aspects</topic><topic>Plasticity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Separation</topic><topic>Spatial Behavior - physiology</topic><topic>Spatial data</topic><topic>Spatial Memory - physiology</topic><topic>Staining</topic><topic>Synapses - physiology</topic><topic>Synaptic plasticity</topic><topic>Synaptic Transmission - physiology</topic><topic>Synaptic vesicles</topic><topic>Synaptophysin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carasatorre, Mariana</creatorcontrib><creatorcontrib>Ochoa-Alvarez, Adrian</creatorcontrib><creatorcontrib>Velázquez-Campos, Giovanna</creatorcontrib><creatorcontrib>Lozano-Flores, Carlos</creatorcontrib><creatorcontrib>Ramírez-Amaya, Víctor</creatorcontrib><creatorcontrib>Díaz-Cintra, Sofía Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carasatorre, Mariana</au><au>Ochoa-Alvarez, Adrian</au><au>Velázquez-Campos, Giovanna</au><au>Lozano-Flores, Carlos</au><au>Ramírez-Amaya, Víctor</au><au>Díaz-Cintra, Sofía Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-05</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0132676</spage><epage>e0132676</epage><pages>e0132676-e0132676</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal network. We first tested this by using the the delayed non-matching to place task (DNMP), in animals that had been previously trained on the water maze (WM) and found that these animals, as well as animals treated as swim controls (SC), performed better than home cage control animals the DNMP task. The "catFISH" imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training. Moreover, these behavioral treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the distal CA3, we found evidence of structural synaptic plasticity that likely includes MF expansion. Finally, the measures of hippocampal network coding obtained with catFISH correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing in the hippocampus.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26244549</pmid><doi>10.1371/journal.pone.0132676</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-08, Vol.10 (8), p.e0132676-e0132676 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1701896263 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Animals Behavior, Animal - physiology Behavioral plasticity Catfish Coding Data processing Exercise Expansion Gene expression Hippocampal plasticity Hippocampus Hippocampus (Brain) Hippocampus - physiology Information processing Male Maze Learning - physiology Memory Mossy Fibers, Hippocampal - physiology Network reliability Neural coding Neuronal Plasticity - physiology Neurophysiology Overtraining Physiological aspects Plasticity Rats Rats, Wistar Rodents Separation Spatial Behavior - physiology Spatial data Spatial Memory - physiology Staining Synapses - physiology Synaptic plasticity Synaptic Transmission - physiology Synaptic vesicles Synaptophysin |
| title | Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T12%3A58%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hippocampal%20Synaptic%20Expansion%20Induced%20by%20Spatial%20Experience%20in%20Rats%20Correlates%20with%20Improved%20Information%20Processing%20in%20the%20Hippocampus&rft.jtitle=PloS%20one&rft.au=Carasatorre,%20Mariana&rft.date=2015-08-05&rft.volume=10&rft.issue=8&rft.spage=e0132676&rft.epage=e0132676&rft.pages=e0132676-e0132676&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0132676&rft_dat=%3Cgale_plos_%3EA432692679%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1701896263&rft_id=info:pmid/26244549&rft_galeid=A432692679&rft_doaj_id=oai_doaj_org_article_3ccf509121ac47c39bfa788e3177bdc5&rfr_iscdi=true |