Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate
Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as the subchondral bone and articular cartilage. The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subc...
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| creator | Jeong, Yong Joon Kim, Inhye Cho, Joon Hyung Park, Dae Won Kwon, Jung Eun Jung, Moon Won Meng, Xue Jo, Se Min Song, Hae Seong Cho, Young Mi Song, Sang Mok Ham, Young-Min Jung, Yong-Hwan Kim, Chang Sook Yoon, Weon-Jong Kang, Se Chan |
| description | Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as the subchondral bone and articular cartilage. The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subchondral bone, to adapt to local biological and biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract of Litsea japonica fruit (LJFE) had beneficial effects on the articular cartilage, including structural changes in the tibial subchondral bone, matrix degradation, and inflammatory responses, in OA by using a rat model of monosodium iodoacetate-induced OA. Our results showed that administration of LJFE increased the bone volume and cross-section thickness, but the mean number of objects per slice in this group was lower than that in the OA control (OAC) group. In addition, the LJFE decreased the expression of inflammatory cytokines. Compared to the OAC group, the group treated with high doses of LJFE (100 and 200 mg/kg) showed a more than 80% inhibition of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Our results suggest that LJFE can be used as a potential anti-osteoarthritic agent. |
| doi_str_mv | 10.1371/journal.pone.0134856 |
| format | Article |
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The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subchondral bone, to adapt to local biological and biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract of Litsea japonica fruit (LJFE) had beneficial effects on the articular cartilage, including structural changes in the tibial subchondral bone, matrix degradation, and inflammatory responses, in OA by using a rat model of monosodium iodoacetate-induced OA. Our results showed that administration of LJFE increased the bone volume and cross-section thickness, but the mean number of objects per slice in this group was lower than that in the OA control (OAC) group. In addition, the LJFE decreased the expression of inflammatory cytokines. Compared to the OAC group, the group treated with high doses of LJFE (100 and 200 mg/kg) showed a more than 80% inhibition of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Our results suggest that LJFE can be used as a potential anti-osteoarthritic agent.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0134856</identifier><identifier>PMID: 26244981</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analgesics ; Animals ; Arthritis ; Biocompatibility ; Biodiversity ; Body Weight - drug effects ; Bone matrix ; Care and treatment ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cartilage, Articular - drug effects ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Cytokines ; Cytokines - blood ; Diagnosis ; Disease Models, Animal ; Elderly ; Enzyme-Linked Immunosorbent Assay ; Ethanol ; Ethanol - chemistry ; Fruit - chemistry ; Fruits ; Gene expression ; Gene Expression - drug effects ; Health aspects ; Inflammation ; Iodoacetic Acid ; Joint diseases ; Laboratory animals ; Life sciences ; Litsea ; Litsea - chemistry ; Male ; Matrix metalloproteinases ; Matrix Metalloproteinases - genetics ; Metalloproteins ; Molecular Structure ; Older people ; Osteoarthritis ; Osteoarthritis - blood ; Osteoarthritis - chemically induced ; Osteoarthritis - prevention & control ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Risk factors ; Rodents ; Subchondral bone ; Tissue Inhibitor of Metalloproteinase-1 - genetics ; Tissue Inhibitor of Metalloproteinase-2 - genetics ; Tissue inhibitor of metalloproteinases ; Tumor necrosis factor-TNF ; X-Ray Microtomography</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0134856</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Jeong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Jeong et al 2015 Jeong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ea58fc8d58748d3b7dcde94b96f6d0b9c024f76c2d62968de94bfa908c574b543</citedby><cites>FETCH-LOGICAL-c692t-ea58fc8d58748d3b7dcde94b96f6d0b9c024f76c2d62968de94bfa908c574b543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526681/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526681/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26244981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tsilibary, Effie C</contributor><creatorcontrib>Jeong, Yong Joon</creatorcontrib><creatorcontrib>Kim, Inhye</creatorcontrib><creatorcontrib>Cho, Joon Hyung</creatorcontrib><creatorcontrib>Park, Dae Won</creatorcontrib><creatorcontrib>Kwon, Jung Eun</creatorcontrib><creatorcontrib>Jung, Moon Won</creatorcontrib><creatorcontrib>Meng, Xue</creatorcontrib><creatorcontrib>Jo, Se Min</creatorcontrib><creatorcontrib>Song, Hae Seong</creatorcontrib><creatorcontrib>Cho, Young Mi</creatorcontrib><creatorcontrib>Song, Sang Mok</creatorcontrib><creatorcontrib>Ham, Young-Min</creatorcontrib><creatorcontrib>Jung, Yong-Hwan</creatorcontrib><creatorcontrib>Kim, Chang Sook</creatorcontrib><creatorcontrib>Yoon, Weon-Jong</creatorcontrib><creatorcontrib>Kang, Se Chan</creatorcontrib><title>Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as the subchondral bone and articular cartilage. The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subchondral bone, to adapt to local biological and biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract of Litsea japonica fruit (LJFE) had beneficial effects on the articular cartilage, including structural changes in the tibial subchondral bone, matrix degradation, and inflammatory responses, in OA by using a rat model of monosodium iodoacetate-induced OA. Our results showed that administration of LJFE increased the bone volume and cross-section thickness, but the mean number of objects per slice in this group was lower than that in the OA control (OAC) group. In addition, the LJFE decreased the expression of inflammatory cytokines. Compared to the OAC group, the group treated with high doses of LJFE (100 and 200 mg/kg) showed a more than 80% inhibition of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Our results suggest that LJFE can be used as a potential anti-osteoarthritic agent.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Biocompatibility</subject><subject>Biodiversity</subject><subject>Body Weight - drug effects</subject><subject>Bone matrix</subject><subject>Care and treatment</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - drug effects</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Diagnosis</subject><subject>Disease Models, Animal</subject><subject>Elderly</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Ethanol</subject><subject>Ethanol - chemistry</subject><subject>Fruit - chemistry</subject><subject>Fruits</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Iodoacetic Acid</subject><subject>Joint diseases</subject><subject>Laboratory animals</subject><subject>Life sciences</subject><subject>Litsea</subject><subject>Litsea - chemistry</subject><subject>Male</subject><subject>Matrix metalloproteinases</subject><subject>Matrix Metalloproteinases - genetics</subject><subject>Metalloproteins</subject><subject>Molecular Structure</subject><subject>Older people</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - chemically induced</subject><subject>Osteoarthritis - prevention & control</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats, Sprague-Dawley</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Subchondral bone</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - genetics</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - genetics</subject><subject>Tissue inhibitor of metalloproteinases</subject><subject>Tumor necrosis factor-TNF</subject><subject>X-Ray Microtomography</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEUhgdR3HX1H4gGBMGL1iSTySQ3Qll2daBSWD9uQyYfbcp0UpOMuPjnTbezSwcUJBcJyXPec_LyFsVLBOeorNH7rR9CL7v53vdmDlFJWEUfFeeIl3hGMSwfn5zPimcxbiGsSkbp0-IMU0wIZ-i8-L3ok5utYjJehrQJLjkFrqw1KkXgLUgbA5YuRSPBVuZWTklwHQaXgOuBBDcygc9em-7ATlQiaHo9KKNBe5uR3kev3bADjddeKpNkMs-LJ1Z20bwY94vi2_XV18tPs-XqY3O5WM4U5TjNjKyYVUxXrCZMl22tlTactJxaqmHLFcTE1lRhTTGn7O7NSg6ZqmrSVqS8KF4fdfedj2L0LQpUQ8Q4hQxmojkSebat2Ae3k-FWeOnE3YUPa5H_5VRnBK80KxHHdaU1qWvCrWa5iUSqlKS2NGt9GLsN7c5oZfoUZDcRnb70biPW_qcgFaaUoSzwZhQI_sdgYvrHyCO1lnkq11ufxdTORSUWpMTZuRofvj7_C5WXNjuncnKsy_eTgneTgswk8yut5RCjaL7c_D-7-j5l356wGyO7tIm-G5LzfZyC5Aiq4GMMxj44h6A4BP_eDXEIvhiDn8tenbr-UHSf9PIP4J7-6g</recordid><startdate>20150805</startdate><enddate>20150805</enddate><creator>Jeong, Yong Joon</creator><creator>Kim, Inhye</creator><creator>Cho, Joon Hyung</creator><creator>Park, Dae Won</creator><creator>Kwon, Jung Eun</creator><creator>Jung, Moon Won</creator><creator>Meng, Xue</creator><creator>Jo, Se Min</creator><creator>Song, Hae Seong</creator><creator>Cho, Young Mi</creator><creator>Song, Sang Mok</creator><creator>Ham, Young-Min</creator><creator>Jung, Yong-Hwan</creator><creator>Kim, Chang Sook</creator><creator>Yoon, Weon-Jong</creator><creator>Kang, Se Chan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150805</creationdate><title>Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate</title><author>Jeong, Yong Joon ; Kim, Inhye ; Cho, Joon Hyung ; Park, Dae Won ; Kwon, Jung Eun ; Jung, Moon Won ; Meng, Xue ; Jo, Se Min ; Song, Hae Seong ; Cho, Young Mi ; Song, Sang Mok ; Ham, Young-Min ; Jung, Yong-Hwan ; Kim, Chang Sook ; Yoon, Weon-Jong ; Kang, Se Chan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ea58fc8d58748d3b7dcde94b96f6d0b9c024f76c2d62968de94bfa908c574b543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Biocompatibility</topic><topic>Biodiversity</topic><topic>Body Weight - drug effects</topic><topic>Bone matrix</topic><topic>Care and treatment</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage diseases</topic><topic>Cartilage, Articular - drug effects</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Diagnosis</topic><topic>Disease Models, Animal</topic><topic>Elderly</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Ethanol</topic><topic>Ethanol - chemistry</topic><topic>Fruit - chemistry</topic><topic>Fruits</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Iodoacetic Acid</topic><topic>Joint diseases</topic><topic>Laboratory animals</topic><topic>Life sciences</topic><topic>Litsea</topic><topic>Litsea - chemistry</topic><topic>Male</topic><topic>Matrix metalloproteinases</topic><topic>Matrix Metalloproteinases - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Yong Joon</au><au>Kim, Inhye</au><au>Cho, Joon Hyung</au><au>Park, Dae Won</au><au>Kwon, Jung Eun</au><au>Jung, Moon Won</au><au>Meng, Xue</au><au>Jo, Se Min</au><au>Song, Hae Seong</au><au>Cho, Young Mi</au><au>Song, Sang Mok</au><au>Ham, Young-Min</au><au>Jung, Yong-Hwan</au><au>Kim, Chang Sook</au><au>Yoon, Weon-Jong</au><au>Kang, Se Chan</au><au>Tsilibary, Effie C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-05</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0134856</spage><pages>e0134856-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as the subchondral bone and articular cartilage. The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subchondral bone, to adapt to local biological and biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract of Litsea japonica fruit (LJFE) had beneficial effects on the articular cartilage, including structural changes in the tibial subchondral bone, matrix degradation, and inflammatory responses, in OA by using a rat model of monosodium iodoacetate-induced OA. Our results showed that administration of LJFE increased the bone volume and cross-section thickness, but the mean number of objects per slice in this group was lower than that in the OA control (OAC) group. In addition, the LJFE decreased the expression of inflammatory cytokines. Compared to the OAC group, the group treated with high doses of LJFE (100 and 200 mg/kg) showed a more than 80% inhibition of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Our results suggest that LJFE can be used as a potential anti-osteoarthritic agent.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26244981</pmid><doi>10.1371/journal.pone.0134856</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-08, Vol.10 (8), p.e0134856 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1701896080 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analgesics Animals Arthritis Biocompatibility Biodiversity Body Weight - drug effects Bone matrix Care and treatment Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Cytokines Cytokines - blood Diagnosis Disease Models, Animal Elderly Enzyme-Linked Immunosorbent Assay Ethanol Ethanol - chemistry Fruit - chemistry Fruits Gene expression Gene Expression - drug effects Health aspects Inflammation Iodoacetic Acid Joint diseases Laboratory animals Life sciences Litsea Litsea - chemistry Male Matrix metalloproteinases Matrix Metalloproteinases - genetics Metalloproteins Molecular Structure Older people Osteoarthritis Osteoarthritis - blood Osteoarthritis - chemically induced Osteoarthritis - prevention & control Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Risk factors Rodents Subchondral bone Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue inhibitor of metalloproteinases Tumor necrosis factor-TNF X-Ray Microtomography |
| title | Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate |
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