Neuregulin 1 Improves Glucose Tolerance in db/db Mice

In vitro experiments using rodent skeletal muscle cells suggest that neuregulin 1 (NRG1) is involved in glucose metabolism regulation, although no study has evaluated the role of NRG1 in systemic glucose homeostasis. The purpose of this study was to investigate the effect of chronic and acute NRG1 t...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0130568-e0130568
Hauptverfasser:	Ennequin, Gaël, Boisseau, Nathalie, Caillaud, Kevin, Chavanelle, Vivien, Etienne, Monique, Li, Xinyan, Sirvent, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue AKT protein Animals Blood glucose Blood Glucose - metabolism Diabetes Epidermal growth factor ErbB protein ErbB-3 protein Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Gene expression Gluconeogenesis Gluconeogenesis - physiology Glucose Glucose metabolism Glucose tolerance Glucose Tolerance Test Homeostasis Hypothalamus Injection Insulin - blood Insulin resistance Liver Liver - metabolism Male Metabolism Mice Muscles Musculoskeletal system Neuregulin Neuregulin 1 Neuregulin-1 - metabolism Neuregulin-1 - physiology Neuromuscular diseases Phosphorylation Proteins Proto-Oncogene Proteins c-akt - metabolism Pyruvic acid Receptors Rodents Saline solutions Skeletal muscle Transcription factors Western blotting
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