The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli
The relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care. We conducted a retrospective study reviewing...
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| Veröffentlicht in: | PloS one 2015-07, Vol.10 (7), p.e0134998-e0134998 |
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| creator | Zhao, Jiang-Nan Zhang, Xian-Xin He, Xiao-Chun Yang, Guo-Ru Zhang, Xiao-Qi Li, Huai-Chen |
| description | The relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care.
We conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014. To identify the relationship between XDR-TB and MDR-GNB, univariable comparison and multivariable logistic regression were performed.
Among 2962 pulmonary TB patients, 45(1.5%) patients had a diagnosis of XDR-TB. A total of 165 MDR-GNB strains were detected in 143 (4.8%) pulmonary TB patients. XDR-TB patients had a significantly higher occurrence of MDR-GNB than non-XDR-TB patients (24.4% vs. 4.5%; P |
| doi_str_mv | 10.1371/journal.pone.0134998 |
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We conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014. To identify the relationship between XDR-TB and MDR-GNB, univariable comparison and multivariable logistic regression were performed.
Among 2962 pulmonary TB patients, 45(1.5%) patients had a diagnosis of XDR-TB. A total of 165 MDR-GNB strains were detected in 143 (4.8%) pulmonary TB patients. XDR-TB patients had a significantly higher occurrence of MDR-GNB than non-XDR-TB patients (24.4% vs. 4.5%; P<0.001). Age (OR 1.02, 95% CI 1.01-1.03), hypoalbuminemia (OR 1.48, 95% CI 1.18-1.85), chronic renal failure (OR 6.67, 95% CI 1.42-31.47), chronic hepatic insufficiency (OR 1.99, 95% CI 1.15-3.43), presence of XDR-TB (OR 6.56, 95% CI 1.61-26.69), and duration of TB diagnostic delay (OR 1.01, 95% CI 1.00-1.02) were the independent risk factors for MDR-GNB infection.
Patients with XDR-TB have a significantly higher risk of being affected by MDR-GNB pathogen. The underlying mechanism association warrant further studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0134998</identifier><identifier>PMID: 26230499</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Analysis ; Antibiotics ; Antitubercular agents ; Bacilli ; Bacterial infections ; Diagnostic systems ; Drug resistance ; Female ; Gram-negative bacilli ; Health aspects ; Health risks ; Humans ; Kidneys ; Male ; Medical diagnosis ; Microbial drug resistance ; Middle Aged ; Multidrug resistance ; Multidrug resistant organisms ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Nosocomial infections ; Patients ; Renal failure ; Retrospective Studies ; Risk analysis ; Risk factors ; Tuberculosis ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - microbiology</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0134998-e0134998</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Zhao et al 2015 Zhao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-50444b7bf22a7b8d5ecee913a0bc7f2b99cb68e0318233f256de62197fa6d9dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521689/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521689/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26230499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Almeida, Adelaide</contributor><creatorcontrib>Zhao, Jiang-Nan</creatorcontrib><creatorcontrib>Zhang, Xian-Xin</creatorcontrib><creatorcontrib>He, Xiao-Chun</creatorcontrib><creatorcontrib>Yang, Guo-Ru</creatorcontrib><creatorcontrib>Zhang, Xiao-Qi</creatorcontrib><creatorcontrib>Li, Huai-Chen</creatorcontrib><title>The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care.
We conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014. To identify the relationship between XDR-TB and MDR-GNB, univariable comparison and multivariable logistic regression were performed.
Among 2962 pulmonary TB patients, 45(1.5%) patients had a diagnosis of XDR-TB. A total of 165 MDR-GNB strains were detected in 143 (4.8%) pulmonary TB patients. XDR-TB patients had a significantly higher occurrence of MDR-GNB than non-XDR-TB patients (24.4% vs. 4.5%; P<0.001). Age (OR 1.02, 95% CI 1.01-1.03), hypoalbuminemia (OR 1.48, 95% CI 1.18-1.85), chronic renal failure (OR 6.67, 95% CI 1.42-31.47), chronic hepatic insufficiency (OR 1.99, 95% CI 1.15-3.43), presence of XDR-TB (OR 6.56, 95% CI 1.61-26.69), and duration of TB diagnostic delay (OR 1.01, 95% CI 1.00-1.02) were the independent risk factors for MDR-GNB infection.
Patients with XDR-TB have a significantly higher risk of being affected by MDR-GNB pathogen. The underlying mechanism association warrant further studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Antibiotics</subject><subject>Antitubercular agents</subject><subject>Bacilli</subject><subject>Bacterial infections</subject><subject>Diagnostic systems</subject><subject>Drug resistance</subject><subject>Female</subject><subject>Gram-negative bacilli</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Microbial drug resistance</subject><subject>Middle Aged</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Nosocomial infections</subject><subject>Patients</subject><subject>Renal failure</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk19v0zAUxSMEYmPwDRBEQkLwkOI_iZO8II0xRqXBpFJ4tRznpvXk2sV2yvbtcdtsatAeUB4SXf_O8fGNb5K8xGiCaYk_XNveGaEna2tggjDN67p6lBzjmpKMEUQfH3wfJc-8v0aooBVjT5MjwghFUXCcmPkS0hloEZQ1fqnWaQPhD4BJz28CGK82oG_Tz65fZDPwygdhQjrvG3Cy1zYWUmHa9Fuvg2rH0IUTq-w7LKLzBtJPQiqt1fPkSSe0hxfD-yT5-eV8fvY1u7y6mJ6dXmaS5ThkBcrzvCmbjhBRNlVbgASoMRWokWVHmrqWDasAUVwRSjtSsBYYwXXZCdbWraQnyeu97zqG5EOrPMclQnmFWFlHYronWiuu-dqplXC33ArFdwXrFly4oKQGTknXlrgmAro2l0CrmAxkUVBoatoULHp9HHbrmxW0EkxwQo9MxytGLfnCbnheEMyqbZh3g4Gzv3vwga-Ul6C1MGD7XW5c1YjlZUTf_IM-fLqBWoh4AGU6G_eVW1N-mhNasqoi29yTB6j4tLBSMt6rTsX6SPB-JIhMgJuwEL33fPpj9v_s1a8x-_aAXYLQYemt7neXcgzme1A6672D7r7JGPHtWNx1g2_Hgg9jEWWvDn_QvehuDuhfi9YJ_w</recordid><startdate>20150731</startdate><enddate>20150731</enddate><creator>Zhao, Jiang-Nan</creator><creator>Zhang, Xian-Xin</creator><creator>He, Xiao-Chun</creator><creator>Yang, Guo-Ru</creator><creator>Zhang, Xiao-Qi</creator><creator>Li, Huai-Chen</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150731</creationdate><title>The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli</title><author>Zhao, Jiang-Nan ; Zhang, Xian-Xin ; He, Xiao-Chun ; Yang, Guo-Ru ; Zhang, Xiao-Qi ; Li, Huai-Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-50444b7bf22a7b8d5ecee913a0bc7f2b99cb68e0318233f256de62197fa6d9dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Antibiotics</topic><topic>Antitubercular agents</topic><topic>Bacilli</topic><topic>Bacterial infections</topic><topic>Diagnostic systems</topic><topic>Drug resistance</topic><topic>Female</topic><topic>Gram-negative bacilli</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Microbial drug resistance</topic><topic>Middle Aged</topic><topic>Multidrug resistance</topic><topic>Multidrug resistant organisms</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Nosocomial infections</topic><topic>Patients</topic><topic>Renal failure</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - microbiology</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jiang-Nan</creatorcontrib><creatorcontrib>Zhang, Xian-Xin</creatorcontrib><creatorcontrib>He, Xiao-Chun</creatorcontrib><creatorcontrib>Yang, Guo-Ru</creatorcontrib><creatorcontrib>Zhang, Xiao-Qi</creatorcontrib><creatorcontrib>Li, Huai-Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jiang-Nan</au><au>Zhang, Xian-Xin</au><au>He, Xiao-Chun</au><au>Yang, Guo-Ru</au><au>Zhang, Xiao-Qi</au><au>Li, Huai-Chen</au><au>Almeida, Adelaide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-31</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0134998</spage><epage>e0134998</epage><pages>e0134998-e0134998</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care.
We conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014. To identify the relationship between XDR-TB and MDR-GNB, univariable comparison and multivariable logistic regression were performed.
Among 2962 pulmonary TB patients, 45(1.5%) patients had a diagnosis of XDR-TB. A total of 165 MDR-GNB strains were detected in 143 (4.8%) pulmonary TB patients. XDR-TB patients had a significantly higher occurrence of MDR-GNB than non-XDR-TB patients (24.4% vs. 4.5%; P<0.001). Age (OR 1.02, 95% CI 1.01-1.03), hypoalbuminemia (OR 1.48, 95% CI 1.18-1.85), chronic renal failure (OR 6.67, 95% CI 1.42-31.47), chronic hepatic insufficiency (OR 1.99, 95% CI 1.15-3.43), presence of XDR-TB (OR 6.56, 95% CI 1.61-26.69), and duration of TB diagnostic delay (OR 1.01, 95% CI 1.00-1.02) were the independent risk factors for MDR-GNB infection.
Patients with XDR-TB have a significantly higher risk of being affected by MDR-GNB pathogen. The underlying mechanism association warrant further studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26230499</pmid><doi>10.1371/journal.pone.0134998</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analysis Antibiotics Antitubercular agents Bacilli Bacterial infections Diagnostic systems Drug resistance Female Gram-negative bacilli Health aspects Health risks Humans Kidneys Male Medical diagnosis Microbial drug resistance Middle Aged Multidrug resistance Multidrug resistant organisms Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Nosocomial infections Patients Renal failure Retrospective Studies Risk analysis Risk factors Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology |
| title | The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli |
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