Panaxadiol Saponin and Dexamethasone Improve Renal Function in Lipopolysaccharide-Induced Mouse Model of Acute Kidney Injury

Acute kidney injury (AKI) is a serious complication of systemic inflammatory response syndrome (SIRS), which has a high mortality rate. Previous studies showed that panaxadiol saponin (PDS) and Dexamethasone have similar anti-inflammatory properties and protect cardiopulmonary function in lipopolysa...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0134653-e0134653
Hauptverfasser:	Chen, Yan, Du, Yanwei, Li, Yang, Wang, Xiaoqin, Gao, Pin, Yang, Guang, Fang, Yuan, Meng, Yan, Zhao, Xuejian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - physiopathology Animals Anti-inflammatory agents Blood Central nervous system depressants Creatinine Cytokines Dexamethasone Dexamethasone - pharmacology Disease Models, Animal Endothelium Ginsenosides - pharmacology Glucocorticoids Health aspects Horticultural industry Inflammation Inflammatory response Inhibition Interleukins Kidney - drug effects Kidney - physiopathology Kidneys Laboratory animals Lipopolysaccharides Lipopolysaccharides - toxicity Malondialdehyde - metabolism Medicine Mice Mice, Inbred C57BL Mitogens NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Nitrogen Nuclei Oxidative stress Pancreatitis Phosphorylation Rats Receptors, Glucocorticoid - metabolism Renal function RNA polymerase Rodents Sepsis Septic shock Signal transduction Signaling Steroids Steroids (Organic compounds) Studies Superoxide dismutase Superoxide Dismutase - metabolism Systemic inflammatory response syndrome Tumor necrosis factor-TNF Tumor necrosis factor-α Urea
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Zusammenfassung:	Acute kidney injury (AKI) is a serious complication of systemic inflammatory response syndrome (SIRS), which has a high mortality rate. Previous studies showed that panaxadiol saponin (PDS) and Dexamethasone have similar anti-inflammatory properties and protect cardiopulmonary function in lipopolysaccharide (LPS)-induced septic shock rats. In the present study, we investigated whether PDS or Dexamethasone has a similar role in improving kidney function in LPS-induced AKI mice. Mice subjected to LPS (10 mg/kg) treatment exhibited AKI demonstrated by markedly increased blood urea nitrogen and creatinine levels compared with controls (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0134653