Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that recognizes DNA lesions and initiates the nucleotide excision repair process. DDB1 is also a component of the CUL4 E3 ligase complex involved in a broad spectrum of cellular processes by targeted ubiquitinati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0134299-e0134299
Hauptverfasser:	Hu, Zhilian, Holzschuh, Jochen, Driever, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Analysis Animals Antisense RNA Apoptosis Apoptosis - genetics B cells Brain Cancer Cell activation Cell cycle Cell Cycle - genetics Cell Proliferation - genetics Cell survival Cyclin-dependent kinase inhibitor p21 Danio rerio Defects Deoxyribonucleic acid Deregulation Developmental biology Disease DNA DNA damage DNA methylation DNA repair DNA-Binding Proteins - genetics Dopamine receptors Drosophila Embryos Ethyl nitrosourea Gene mutation Genes Genes, p53 Genetic aspects Genomes Genotype & phenotype Insects Jaw Kinases Lesions Ligases Medical research Morphology Mutagenesis Mutants Nucleotide excision repair p53 Protein Proliferating cell nuclear antigen Protein binding Proteins Regulators Splicing Tissues Transcription (Genetics) Transcription activation Transcription, Genetic Transcriptional Activation Tumor proteins Tumor suppressor genes Ubiquitin Ubiquitin-protein ligase Ubiquitination Viability Zebrafish Zebrafish - embryology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!