Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways

Acute renal failure is a serious complication of the anticancer drug cisplatin. The potential role of baicalein, a naturally occurring bioflavonoid on cisplatin-induced renal injury is unknown. Here, we assessed the effect of baicalein against a murine model of cisplatin-induced acute renal failure...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0134139-e0134139
Hauptverfasser:	Sahu, Bidya Dhar, Mahesh Kumar, Jerald, Sistla, Ramakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - prevention & control Animal models Animals Antineoplastic Agents - adverse effects Antioxidants Antioxidants - metabolism Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Caspase Caspase-3 Caspase-9 Cisplatin Cisplatin - adverse effects Cytochrome Cytochrome c Cytotoxicity Deoxyribonucleic acid DNA Down-Regulation - drug effects Flavanones - pharmacology Flavonoids - pharmacology Histology Infiltration Inflammation Injury prevention Interleukin 6 Intracellular signalling JNK protein Kidney - drug effects Kidney - metabolism Kidneys Kinases Laboratory animals Male MAP kinase Mice Mice, Inbred BALB C Mitochondria Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism NF-κB protein Nitric-oxide synthase Nuclear transport Oxidative stress Oxidative Stress - drug effects Pharmaceutical sciences Phosphorylation Phosphorylation - drug effects Poly(ADP-ribose) polymerase Proteins Renal failure Renal function Rodents Signal transduction Signal Transduction - drug effects Translocation Up-Regulation - drug effects
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