Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project
The Multidimensional Prognostic Index (MPI) has been found to predict mortality in patients with a variety of clinical conditions. We aimed to assess the association of the MPI with future mortality and number of in-hospital days for the first time in a population-based cohort. The study population...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-07, Vol.10 (7), p.e0133789-e0133789 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0133789 |
|---|---|
| container_issue | 7 |
| container_start_page | e0133789 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Angleman, Sara B Santoni, Giola Pilotto, Alberto Fratiglioni, Laura Welmer, Anna-Karin |
| description | The Multidimensional Prognostic Index (MPI) has been found to predict mortality in patients with a variety of clinical conditions. We aimed to assess the association of the MPI with future mortality and number of in-hospital days for the first time in a population-based cohort.
The study population consisted of 2472 persons, aged 66-99 years, from the Swedish National Study on Aging and Care in Kungsholmen, Sweden, who underwent the baseline visit 2001-4, and were followed up >10 years for in-hospital days and >12 years for mortality. The MPI was a modified version of the original and aggregated seven domains (personal and instrumental activities of daily living, cognitive function, illness severity and comorbidity, number of medications, co-habitation status, and nutritional status). The MPI score was divided into risk groups: low, medium and high. Number of in-hospital days (within 1, 3 and 10 years) and mortality data were derived from official registries. All analyses were age-stratified (sexagenarians, septuagenarians, octogenarians, nonagenarians).
During the follow-up 1331 persons (53.8%) died. Laplace regression models, suggested that median survival in medium risk groups varied by age from 2.2-3.6 years earlier than for those in the corresponding low risk groups (p = 0.002-p |
| doi_str_mv | 10.1371/journal.pone.0133789 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1700107419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A455367931</galeid><doaj_id>oai_doaj_org_article_6a847383b0e74353ba63644884a0b6c6</doaj_id><sourcerecordid>A455367931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c767t-ce0847f627e58f30660860893e8258b2f22b94a0ddca4196c9f1be27702452243</originalsourceid><addsrcrecordid>eNqNk-1q1EAUhoMotlbvQHRAEAV3na9MEn8Iaz8XWlta27_DJJnszjbJxMzEtpfm3XnSTUsjFSSBHGae952TNzlB8JrgKWER-byyXVurctrYWk8xYSyKkyfBJkkYnQiK2dMH9UbwwrkVxiGLhXgebFBBKQ252Ax-H3WlN7mpdO2MBT900tpFbZ03GZrXub5GpkYz52xmlAcCXRm_RHud71qNjmzrVWn8DVJ1jr53VapbZAt0YF1jYAftqBvXGyh0YpuuvHWYfFNO5-hMVU2pe_q4zEE2y6ET9wWdatcX_YZfarR7DodBHzk6OpnL2f5u3-BKZ_5l8KxQpdOvhudWcL63-2P7YHJ4vD_fnh1OskhEfpJpHPOoEDTSYVwwLASO4U6YjmkYp7SgNE24wnmeKU4SkSUFSTWNIkx5SClnW8HbtW9TWieH1J0kEcYERyABYr4mcqtWsmlNpdobaZWRtwu2XUjVQp6llkJBMyxmKdYRZyFLlWCC8ziGDlKRCfCarL3clW66dOQ2LF1CpWVIoIMY-E__5HfMxez2dNdJQjHkAPjX4WW6tNJ5pmvfqnKkGu_UZikX9pfkIUkwp2DwYTBo7c9OOy8r4zJdlqrWtlvHImIeRxjQd3-hj4c3UAsF-Zi6sHBu1pvKGQ9DJqKEEaCmj1Bw5boyGUxAYWB9JPg4EgDj9bVfqM45OT87_X_2-GLMvn_ALrUq_dLZsut_bDcG-RrMWutcq4v7kAmW_QDfpSH7AZbDAIPszcMPdC-6m1j2B1SgQIE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1700107419</pqid></control><display><type>article</type><title>Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project</title><source>PLoS</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>SWEPUB Freely available online</source><source>EZB Electronic Journals Library</source><creator>Angleman, Sara B ; Santoni, Giola ; Pilotto, Alberto ; Fratiglioni, Laura ; Welmer, Anna-Karin</creator><creatorcontrib>Angleman, Sara B ; Santoni, Giola ; Pilotto, Alberto ; Fratiglioni, Laura ; Welmer, Anna-Karin ; MPI_AGE Project Investigators ; on behalf of the MPI_AGE Project Investigators</creatorcontrib><description>The Multidimensional Prognostic Index (MPI) has been found to predict mortality in patients with a variety of clinical conditions. We aimed to assess the association of the MPI with future mortality and number of in-hospital days for the first time in a population-based cohort.
The study population consisted of 2472 persons, aged 66-99 years, from the Swedish National Study on Aging and Care in Kungsholmen, Sweden, who underwent the baseline visit 2001-4, and were followed up >10 years for in-hospital days and >12 years for mortality. The MPI was a modified version of the original and aggregated seven domains (personal and instrumental activities of daily living, cognitive function, illness severity and comorbidity, number of medications, co-habitation status, and nutritional status). The MPI score was divided into risk groups: low, medium and high. Number of in-hospital days (within 1, 3 and 10 years) and mortality data were derived from official registries. All analyses were age-stratified (sexagenarians, septuagenarians, octogenarians, nonagenarians).
During the follow-up 1331 persons (53.8%) died. Laplace regression models, suggested that median survival in medium risk groups varied by age from 2.2-3.6 years earlier than for those in the corresponding low risk groups (p = 0.002-p<0.001), and median survival in high risk groups varied by age from 3.8-9.0 years earlier than for corresponding low risk groups (p<0.001). For nonagenarians, the median age at death was 3.8 years earlier in the high risk group than for the low risk group (p<0.001). The mean number of in-hospital days increased significantly with higher MPI risk score within 1 and 3 years for people of each age group.
For the first time, the effectiveness of MPI has been verified in a population-based cohort. Higher MPI risk scores associated with more days in hospital and with fewer years of survival, across a broad and stratified age range.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0133789</identifier><identifier>PMID: 26222546</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Activities of daily living ; Adults ; Age ; Aged ; Aged, 80 and over ; Aging ; Analysis ; Cognitive ability ; Dementia ; Diabetes ; Epidemiologic Studies ; European Union - economics ; Female ; Frailty ; Hospitalization ; Hospitals ; Humans ; Length of Stay ; Life expectancy ; Male ; Management ; Medical prognosis ; Models, Statistical ; Mortality ; Neurobiology ; Neurosciences ; Nursing homes ; Nutritional status ; Older people ; Population ; Population studies ; Prognosis ; Regression analysis ; Regression models ; Risk ; Risk groups ; Society ; Studies ; Survival ; Sweden - epidemiology</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0133789-e0133789</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Angleman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Angleman et al 2015 Angleman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c767t-ce0847f627e58f30660860893e8258b2f22b94a0ddca4196c9f1be27702452243</citedby><cites>FETCH-LOGICAL-c767t-ce0847f627e58f30660860893e8258b2f22b94a0ddca4196c9f1be27702452243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519042/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519042/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26222546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-120084$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131763954$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Angleman, Sara B</creatorcontrib><creatorcontrib>Santoni, Giola</creatorcontrib><creatorcontrib>Pilotto, Alberto</creatorcontrib><creatorcontrib>Fratiglioni, Laura</creatorcontrib><creatorcontrib>Welmer, Anna-Karin</creatorcontrib><creatorcontrib>MPI_AGE Project Investigators</creatorcontrib><creatorcontrib>on behalf of the MPI_AGE Project Investigators</creatorcontrib><title>Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The Multidimensional Prognostic Index (MPI) has been found to predict mortality in patients with a variety of clinical conditions. We aimed to assess the association of the MPI with future mortality and number of in-hospital days for the first time in a population-based cohort.
The study population consisted of 2472 persons, aged 66-99 years, from the Swedish National Study on Aging and Care in Kungsholmen, Sweden, who underwent the baseline visit 2001-4, and were followed up >10 years for in-hospital days and >12 years for mortality. The MPI was a modified version of the original and aggregated seven domains (personal and instrumental activities of daily living, cognitive function, illness severity and comorbidity, number of medications, co-habitation status, and nutritional status). The MPI score was divided into risk groups: low, medium and high. Number of in-hospital days (within 1, 3 and 10 years) and mortality data were derived from official registries. All analyses were age-stratified (sexagenarians, septuagenarians, octogenarians, nonagenarians).
During the follow-up 1331 persons (53.8%) died. Laplace regression models, suggested that median survival in medium risk groups varied by age from 2.2-3.6 years earlier than for those in the corresponding low risk groups (p = 0.002-p<0.001), and median survival in high risk groups varied by age from 3.8-9.0 years earlier than for corresponding low risk groups (p<0.001). For nonagenarians, the median age at death was 3.8 years earlier in the high risk group than for the low risk group (p<0.001). The mean number of in-hospital days increased significantly with higher MPI risk score within 1 and 3 years for people of each age group.
For the first time, the effectiveness of MPI has been verified in a population-based cohort. Higher MPI risk scores associated with more days in hospital and with fewer years of survival, across a broad and stratified age range.</description><subject>Accuracy</subject><subject>Activities of daily living</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Analysis</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Diabetes</subject><subject>Epidemiologic Studies</subject><subject>European Union - economics</subject><subject>Female</subject><subject>Frailty</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Life expectancy</subject><subject>Male</subject><subject>Management</subject><subject>Medical prognosis</subject><subject>Models, Statistical</subject><subject>Mortality</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Nursing homes</subject><subject>Nutritional status</subject><subject>Older people</subject><subject>Population</subject><subject>Population studies</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk</subject><subject>Risk groups</subject><subject>Society</subject><subject>Studies</subject><subject>Survival</subject><subject>Sweden - epidemiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk-1q1EAUhoMotlbvQHRAEAV3na9MEn8Iaz8XWlta27_DJJnszjbJxMzEtpfm3XnSTUsjFSSBHGae952TNzlB8JrgKWER-byyXVurctrYWk8xYSyKkyfBJkkYnQiK2dMH9UbwwrkVxiGLhXgebFBBKQ252Ax-H3WlN7mpdO2MBT900tpFbZ03GZrXub5GpkYz52xmlAcCXRm_RHud71qNjmzrVWn8DVJ1jr53VapbZAt0YF1jYAftqBvXGyh0YpuuvHWYfFNO5-hMVU2pe_q4zEE2y6ET9wWdatcX_YZfarR7DodBHzk6OpnL2f5u3-BKZ_5l8KxQpdOvhudWcL63-2P7YHJ4vD_fnh1OskhEfpJpHPOoEDTSYVwwLASO4U6YjmkYp7SgNE24wnmeKU4SkSUFSTWNIkx5SClnW8HbtW9TWieH1J0kEcYERyABYr4mcqtWsmlNpdobaZWRtwu2XUjVQp6llkJBMyxmKdYRZyFLlWCC8ziGDlKRCfCarL3clW66dOQ2LF1CpWVIoIMY-E__5HfMxez2dNdJQjHkAPjX4WW6tNJ5pmvfqnKkGu_UZikX9pfkIUkwp2DwYTBo7c9OOy8r4zJdlqrWtlvHImIeRxjQd3-hj4c3UAsF-Zi6sHBu1pvKGQ9DJqKEEaCmj1Bw5boyGUxAYWB9JPg4EgDj9bVfqM45OT87_X_2-GLMvn_ALrUq_dLZsut_bDcG-RrMWutcq4v7kAmW_QDfpSH7AZbDAIPszcMPdC-6m1j2B1SgQIE</recordid><startdate>20150729</startdate><enddate>20150729</enddate><creator>Angleman, Sara B</creator><creator>Santoni, Giola</creator><creator>Pilotto, Alberto</creator><creator>Fratiglioni, Laura</creator><creator>Welmer, Anna-Karin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ABAVF</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG7</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20150729</creationdate><title>Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project</title><author>Angleman, Sara B ; Santoni, Giola ; Pilotto, Alberto ; Fratiglioni, Laura ; Welmer, Anna-Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c767t-ce0847f627e58f30660860893e8258b2f22b94a0ddca4196c9f1be27702452243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accuracy</topic><topic>Activities of daily living</topic><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Analysis</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Diabetes</topic><topic>Epidemiologic Studies</topic><topic>European Union - economics</topic><topic>Female</topic><topic>Frailty</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Life expectancy</topic><topic>Male</topic><topic>Management</topic><topic>Medical prognosis</topic><topic>Models, Statistical</topic><topic>Mortality</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Nursing homes</topic><topic>Nutritional status</topic><topic>Older people</topic><topic>Population</topic><topic>Population studies</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk</topic><topic>Risk groups</topic><topic>Society</topic><topic>Studies</topic><topic>Survival</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Angleman, Sara B</creatorcontrib><creatorcontrib>Santoni, Giola</creatorcontrib><creatorcontrib>Pilotto, Alberto</creatorcontrib><creatorcontrib>Fratiglioni, Laura</creatorcontrib><creatorcontrib>Welmer, Anna-Karin</creatorcontrib><creatorcontrib>MPI_AGE Project Investigators</creatorcontrib><creatorcontrib>on behalf of the MPI_AGE Project Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Stockholms universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Stockholms universitet</collection><collection>SwePub Articles full text</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Angleman, Sara B</au><au>Santoni, Giola</au><au>Pilotto, Alberto</au><au>Fratiglioni, Laura</au><au>Welmer, Anna-Karin</au><aucorp>MPI_AGE Project Investigators</aucorp><aucorp>on behalf of the MPI_AGE Project Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-29</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0133789</spage><epage>e0133789</epage><pages>e0133789-e0133789</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The Multidimensional Prognostic Index (MPI) has been found to predict mortality in patients with a variety of clinical conditions. We aimed to assess the association of the MPI with future mortality and number of in-hospital days for the first time in a population-based cohort.
The study population consisted of 2472 persons, aged 66-99 years, from the Swedish National Study on Aging and Care in Kungsholmen, Sweden, who underwent the baseline visit 2001-4, and were followed up >10 years for in-hospital days and >12 years for mortality. The MPI was a modified version of the original and aggregated seven domains (personal and instrumental activities of daily living, cognitive function, illness severity and comorbidity, number of medications, co-habitation status, and nutritional status). The MPI score was divided into risk groups: low, medium and high. Number of in-hospital days (within 1, 3 and 10 years) and mortality data were derived from official registries. All analyses were age-stratified (sexagenarians, septuagenarians, octogenarians, nonagenarians).
During the follow-up 1331 persons (53.8%) died. Laplace regression models, suggested that median survival in medium risk groups varied by age from 2.2-3.6 years earlier than for those in the corresponding low risk groups (p = 0.002-p<0.001), and median survival in high risk groups varied by age from 3.8-9.0 years earlier than for corresponding low risk groups (p<0.001). For nonagenarians, the median age at death was 3.8 years earlier in the high risk group than for the low risk group (p<0.001). The mean number of in-hospital days increased significantly with higher MPI risk score within 1 and 3 years for people of each age group.
For the first time, the effectiveness of MPI has been verified in a population-based cohort. Higher MPI risk scores associated with more days in hospital and with fewer years of survival, across a broad and stratified age range.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26222546</pmid><doi>10.1371/journal.pone.0133789</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-07, Vol.10 (7), p.e0133789-e0133789 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1700107419 |
| source | PLoS; MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Directory of Open Access Journals; SWEPUB Freely available online; EZB Electronic Journals Library |
| subjects | Accuracy Activities of daily living Adults Age Aged Aged, 80 and over Aging Analysis Cognitive ability Dementia Diabetes Epidemiologic Studies European Union - economics Female Frailty Hospitalization Hospitals Humans Length of Stay Life expectancy Male Management Medical prognosis Models, Statistical Mortality Neurobiology Neurosciences Nursing homes Nutritional status Older people Population Population studies Prognosis Regression analysis Regression models Risk Risk groups Society Studies Survival Sweden - epidemiology |
| title | Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T16%3A03%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multidimensional%20Prognostic%20Index%20in%20Association%20with%20Future%20Mortality%20and%20Number%20of%20Hospital%20Days%20in%20a%20Population-Based%20Sample%20of%20Older%20Adults:%20Results%20of%20the%20EU%20Funded%20MPI_AGE%20Project&rft.jtitle=PloS%20one&rft.au=Angleman,%20Sara%20B&rft.aucorp=MPI_AGE%20Project%20Investigators&rft.date=2015-07-29&rft.volume=10&rft.issue=7&rft.spage=e0133789&rft.epage=e0133789&rft.pages=e0133789-e0133789&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0133789&rft_dat=%3Cgale_plos_%3EA455367931%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1700107419&rft_id=info:pmid/26222546&rft_galeid=A455367931&rft_doaj_id=oai_doaj_org_article_6a847383b0e74353ba63644884a0b6c6&rfr_iscdi=true |