Patient-Derived Gastric Carcinoma Xenograft Mouse Models Faithfully Represent Human Tumor Molecular Diversity

Patient-derived cancer xenografts (PDCX) generally represent more reliable models of human disease in which to evaluate a potential drugs preclinical efficacy. However to date, only a few patient-derived gastric cancer xenograft (PDGCX) models have been reported. In this study, we aimed to establish...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0134493-e0134493
Hauptverfasser:	Zhang, Tianwei, Zhang, Lin, Fan, Shuqiong, Zhang, Meizhuo, Fu, Haihua, Liu, Yuanjie, Yin, Xiaolu, Chen, Hao, Xie, Liang, Zhang, Jingchuan, Gavine, Paul R, Gu, Yi, Ni, Xingzhi, Su, Xinying
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Animal models Animal tissues Animals Biocompatibility Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical materials Cancer Cancer patients Colorectal cancer Copy number Cytogenetics Drug development Drugs Emerging markets Epidermal growth factor Epidermal growth factor receptors ErbB-1 protein ErbB-2 protein ErbB-3 protein Female Fibroblast growth factor receptor 2 Fluorescence Fluorescence in situ hybridization Gastric cancer Gene amplification Gene expression Genetic diversity Hospitals Humans Immunoenzyme Techniques Immunohistochemistry Immunosuppressive agents In Situ Hybridization, Fluorescence In vivo methods and tests Lymphatic Metastasis Male MET protein Mice Mice, Nude Mice, SCID Middle Aged Molecular modelling Multiculturalism & pluralism Neoplasm Grading Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Patients Prognosis PTEN protein R&D Research & development Stomach cancer Stomach Neoplasms - classification Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Survival Rate Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays Xenografts
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