Significant Correlation between Retinal Venous Tortuosity and Aqueous Vascular Endothelial Growth Factor Concentration in Eyes with Central Retinal Vein Occlusion

To determine whether the degree of venous tortuosity is significantly correlated with the aqueous vascular endothelial growth factor (VEGF) concentration in eyes with a central retinal vein occlusion (CRVO). We reviewed the medical records of 32 eyes of 32 patients who had macular edema due to a CRV...

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Veröffentlicht in:PloS one 2015-07, Vol.10 (7), p.e0134267-e0134267
Hauptverfasser: Yasuda, Shunsuke, Kachi, Shu, Kondo, Mineo, Ueno, Shinji, Kaneko, Hiroki, Terasaki, Hiroko
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Kachi, Shu
Kondo, Mineo
Ueno, Shinji
Kaneko, Hiroki
Terasaki, Hiroko
description To determine whether the degree of venous tortuosity is significantly correlated with the aqueous vascular endothelial growth factor (VEGF) concentration in eyes with a central retinal vein occlusion (CRVO). We reviewed the medical records of 32 eyes of 32 patients who had macular edema due to a CRVO. All of the patients were examined at the Nagoya University Hospital and were scheduled to receive an intravitreal injection of bevacizumab (IVB) or ranibizumab (IVR) within 12 weeks of the onset of the CRVO to treat the macular edema. Aqueous humor was collected just before the IVB or IVR, and the VEGF concentration was determined by enzyme-linked immunosorbent assay (ELISA). The venous tortuosity index was calculated by dividing the length of the retinal veins by the chord length of the same segment. The correlation between the mean tortuosity index of the inferotemporal and supratemporal branches of the retinal vein and the aqueous VEGF concentration was determined. The mean aqueous VEGF concentration was 384 ± 312 pg/ml with a range of 90 to 1077 pg/ml. The degree of venous tortuosity was significantly correlated with the VEGF concentration in the aqueous. (r = 0.49, P = 0.004), with the foveal thickness (r = 0.40, P = 0.02), and with the best-corrected visual acuity (r = 0.38, P = 0.03). The significant correlation between the aqueous VEGF concentration and the venous tortuosity indicates that the degree of retinal venous tortuosity can be used to identify eyes that are at a high risk of developing neovascularization.
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(r = 0.49, P = 0.004), with the foveal thickness (r = 0.40, P = 0.02), and with the best-corrected visual acuity (r = 0.38, P = 0.03). The significant correlation between the aqueous VEGF concentration and the venous tortuosity indicates that the degree of retinal venous tortuosity can be used to identify eyes that are at a high risk of developing neovascularization.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26214803</pmid><doi>10.1371/journal.pone.0134267</doi><oa>free_for_read</oa></addata></record>
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subjects Acuity
Aged
Aged, 80 and over
Bevacizumab
Bevacizumab - administration & dosage
Correlation
Diabetes
Diabetic retinopathy
Edema
Enzyme-linked immunosorbent assay
Enzymes
Eye
Eye (anatomy)
Family medical history
Female
Humans
Macular Edema - drug therapy
Macular Edema - metabolism
Macular Edema - pathology
Male
Medical imaging
Medical records
Medicine
Middle Aged
Monoclonal antibodies
Neovascularization
Occlusion
Optics
Patients
Radiography
Ranibizumab - administration & dosage
Retina
Retinal diseases
Retinal Vein - diagnostic imaging
Retinal Vein - metabolism
Retinal Vein Occlusion - diagnostic imaging
Retinal Vein Occlusion - drug therapy
Retinal Vein Occlusion - metabolism
Tomography
Tortuosity
University graduates
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
Vascularization
Veins & arteries
Visual acuity
title Significant Correlation between Retinal Venous Tortuosity and Aqueous Vascular Endothelial Growth Factor Concentration in Eyes with Central Retinal Vein Occlusion
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T19%3A51%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Significant%20Correlation%20between%20Retinal%20Venous%20Tortuosity%20and%20Aqueous%20Vascular%20Endothelial%20Growth%20Factor%20Concentration%20in%20Eyes%20with%20Central%20Retinal%20Vein%20Occlusion&rft.jtitle=PloS%20one&rft.au=Yasuda,%20Shunsuke&rft.date=2015-07-27&rft.volume=10&rft.issue=7&rft.spage=e0134267&rft.epage=e0134267&rft.pages=e0134267-e0134267&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0134267&rft_dat=%3Cgale_plos_%3EA423309634%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1699201215&rft_id=info:pmid/26214803&rft_galeid=A423309634&rft_doaj_id=oai_doaj_org_article_fb7f631fb80547c8858265d52d2f3b1d&rfr_iscdi=true